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Old 02-11-2009, 11:08 AM   #1
Rich66
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Just a thought..
Seems like info keeps coming out about the evolution of tumors and how adding or withdrawing certain agents for various time periods can resensitize tumors to certain agents. I sometimes wonder if a constantly rotating series of chemos could keep the tumor from having enough time to develop resistance. You know..instead of continuous left jabs, ultimate fighting. Ok..goofy analogy.
Have you investigated directed liver therapies like SIR spheres, LC beads, intra arterial chemo or :

http://her2support.org/vbulletin/showthread.php?t=37938
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Old 02-11-2009, 06:33 PM   #2
julierene
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I think that's what they used to do in the old days, and it was too toxic for people, and still the tumors would grow resistant. Let me know if I am wrong on that. Julie
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Jan04: Bilateral Mastectomy at age 28
Initial DX: Left Breast: IDC 2cm, Grade 3, HER2+3, 0 Nodes +, ER/PR-. Right Breast: Extensive DCIS ER-/PR+; Stage 1-2a
Feb04-Apr04: 4 AC, dose dense
Aug 04: 4 Taxotere
Dec 05: Bone and Liver METS; Stage 4. Carboplatin/Taxol/Herceptin. DX with Li-Fraumeni Syndrome
Apr 06: NED, maintenance Herceptin
Apr 07: CA1503=14; masses in liver; Xeloda/Tykerb
Nov 07: NED, Tykerb maintenance
Sept 08: Liver mets again, on Tykerb/Xeloda again, CA=19 and 27
Nov 08: Progression, Tykerb/Gemzar, CA=25
Dec 08: Progression, Herceptin/Navelbine, CA=40, 57, and 130
Jan 09: Progression in bone, recession in liver, Herceptin/Carbo/Abraxane CA=135
June 09: CA27/29=24, chemo break
Sept 09: Progression, CA=24, waiting on clinical trial (4 weeks no treatment)
Nov 09: now have brain mets, trial "on hold", getting 14 WBR treatments starting 11/2/09
Dec 09: possible start on p53 trial
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Old 02-12-2009, 09:12 AM   #3
Joy
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Glad you brought this up

and happy to see the responses. My onc had also said after two years it is worth a try. I feel like we are so alike in these things. I am currantly on Epirubicin (basically adriamycin)/Cytoxan/Herceptin and have wondered and wondered if this can really work. I was on A/C 8 years ago, so I know this time frame could make a difference. I try to look at it on the occassionaly positive days as a starting over fresh, but with more information than we had when I was stage I and we were just doing protocol and did not know I was her2 positive.

I am thrilled with your scan results amd hope they offere a sense of relief and encouragement. Keep up the good work beautiful and thank you for invoking the responses. And thanks to all the responders as well.
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dx stage I 2/2000*er/pr+; her- per IHC*lumpectomy*4 rounds A/C*30 rads*tamoxifen*dx stage 4 5/2002*huge mets to liver*tiny mets to lungs*stopped tamoxifen*5/02 taxotere/xeloda*her 2 checked with FiSH-her2+++herceptin *2/03 stopped chemo femara w/herceptin*zolodex*04 switched to aromasin w/herceptin*05 high estrogen tx*11/05taxol/carbo*7/06 stopped chemo; megace/herceptin*9/06navelbine/herceptin*5/07tykerb/xeloda great response*4/08 progression in liver; ooph/ faslodex /herceptin
6/08 began Herceptin DM-1
9/08 progression
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