Tykerb side effects??? Help, please

[hutchibk]

Adriana - here's the info from the EGFR Therapy Rash wall chart that I transcribed last year... maybe it will give you some answers.

http://theoncologist.alphamedpress.o...12/5/610/DC1/2

*Employ a proactive approach in managing skin reactions.
*Suggest that patients use a thick, alcohol-free emollient cream.
*Suggest that patients use a sunscreen of SPF 25 or higher, preferably
containing zinc oxide or titanium dioxide
* If patient presents with rash, verify appropriate administration of drug and proceed with the following therapy algorithm:

Mild:
Minimally located
No impact on activities of daily life (ADL)
No sign of superinfection

(shows picture of mild rash occurrence across bridge of nose and cheeks)

Continue EGFR targeted treatment @current dose and monitor for change in severity.

topical hydrocortisone 1% or 2.5% cream and/or Clindamycin 1% gel

Reassess after 2 weeks, if reaction worsens or does not improve, proceed to next step.


Moderate:
Generalized
Mild Symptoms (e.g. pruritus, tenderness)
Minimal impact on ADL
No sign of superinfection

(shows picture of red worsened rash occurrence (pruritus) across nose, around nostrils, top lip, lower cheeks, and entire chin.)

Continue EGFR targeted treatment @current dose and monitor for change in severity. Continue treatment of the skin reaction with the following:

Hydrocortisone 2.5% cream or Clindamycin 1$ gel
or Pimecrolimus 1% cream
Plus Doxycycline 100mg BID or Monocycline 100mg BID

Reassess after 2 weeks, if reaction worsens or does not improve, proceed to next step.


Severe:
Generalized
Severe symptoms (e.g. pruritus, tenderness)
Significant impact on ADL
Potential sign of superinfection

(shows picture of worsened rash occurrence similar to moderate with more facial coverage and continuation to shoulders and neck)

Reduce EGFR targeted therapy as per label and monitor for change in severity. Continue treatment of skin reaction with the following:

Hydrocortisone 2.5% cream or Clindamycin 1$ gel
or Pimecrolimus 1% cream
Plus Doxycycline 100mg BID or Monocycline 100mg BID
Plus Medrol dose pack

Reassess after 2 weeks, if reaction worsens, dose interruption or discontinuation may be necessary.

[Joy]

Minocycline worked pretty well for me as I had developed an acne like rash. Also, sun exposure caused flare ups, so a good non-greasy sunscreen helped some too. I hope these things work for you!

[vickie h]

Adrianna, I tried a product called Suki facial moisture serum with carrot, myrrh and sandalwood. It cleared up the rash and acne like symptoms immediately. It is an amazing product and can usually be found at health food stores or you can google it to find out where to get it. It is so amazing that my Onc now tells all her patients about it when they start tykerb. You will love it, it is so soothing and healing. Love, Vickie

[CourtneyL]

Vickie H - Your advice was spot on! Thank you so much for your post. I've been on Tykerb for almost two weeks now and thought I was in the clear on the side effects thing until I developed a huge rash this past weekend. I remembered reading your post and promptly got myself some of the Suki stuff from Whole Foods and it is working wonders. Only two days of application and the rash is nearly gone. You are wonderful. Thank you SO much!

[vickie h]

Courtney, You are more than welcome! I'm so glad you got some of the oil. It is truly amazing and the only thing that works immediately (and it's all organic and natural). Everyone I know that has been on Tykerb has gone out and purchased some and the results are phenomenal. For anyone reading this PLEASE GET SOME SUKI OIL! Put it on twice, or more, times a day everyday. It only takes a drop or two. Love, Vickie