|
One of the common features of cancer cells is that they don’t die, apoptosis, at rates of normal cells. Cancer cells can be thought of as immortal. For normal non-cancerous cells TRAIL is a cytokine that binds to DR4 and DR5 receptors and forms a complex (ligand) that sends out death signals. In many cancer cells the DR4 and DR5 receptors have point mutations that prevent TRAIL from binding, thus no death signal. Scientists have been working on creating a variants of TRAIL that will bind to these mutated receptors and have hitched it to a monoclonal antibody to deliver it to the cancer cell. These variants of TRAIL bind the cancer DR5 receptor and not healthy cells receptor and result in the cell death complex to form sending out signals to the cancer cell to die. In this study they showed that combining the her2 antibody and and a DR5 antibody with the TRAIL variant resulted in a compete response in mice, while treatment with either agent alone only slowed growth. This is exciting for all types of cancer not just her2 BC.
Lani or others please correct any misstatements I might have made.
__________________
KK1
April 2004 de novo metastatic left breast 1.5cm her2++,er+/pr+ with 2 small liver mets
weekly taxotere,herceptin, xeloda
Sept 2004 NED-3 herceptin, zoladex,aromasin
Dec 2006 recurrence in liver
Feb. 2007 liver resection left lobe removed-herceptin, zoladex, switch to Arimidex
NED 16 months added zometa
May 2008 new lesion in liver 15mm Tykerb/Xeloda/Herceptin
July 2008 stable...yeah!
Sept 2008 NED again !!!
Jan 2009 fell off the wagon again spot back in the liver and fell out of menopause.
Feb 2009 RFA and 2nd liver resection to remove spot ---back on the NED wagon again continue Tykerb, Herceptin.
March 2009- oophrectomy added Femara and bi-annual Zometa
May 2009- scans clear but suspect lung nodule
June 2009- Lung VAT wedge resection to remove nodule---fungus ball not cancer!! phew
Aug 2009- NED
Nov 2009-scans again clear YAHOO!
March 2010- scans clear continue Tykerb, Herceptin, Femara, Zometa Q6mo
Nov 2009-Nov 2019 scans clear done every 6 months
Feb 2020 - Fell out of the NED wagon hard! single liver lesions and large infect cyst. 3 weeks in ICU.
March 2021- 5 cycles perjeta, herceptin, navelbine. lesion stable.
June 2021 - 3rd liver resection to remove single liver lesion. Continued perjeta, herceptin.
Nov. 2021- PET scan show 5 hot nodes near liver. 9 cycles Kadcyla
June 2021- PET scan shows progression. nodes size unchanged but even more SUV uptake.
July 2021- start ENHERTU
Last edited by kk1; 10-20-2008 at 08:30 AM..
|
Hybrid Mode
