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03-14-2008, 06:25 PM
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#1
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Senior Member
Join Date: Sep 2005
Location: South Dakota.
Posts: 621
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Drugs that cross the Blood Brain Barrier
I had this listed amoungst my favorites which I was going through...it might be helpful...
http://cpharm.vetmed.vt.edu/VM9096/handout.htm
__________________
Blessings and Peace,
Barbara
DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.
Accepting the gift of life, I give thanks for it and live it in fullness.
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03-14-2008, 08:41 PM
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#2
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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Bbb
Thanks, Barbara! I wonder when this list was made.
I had an experience that I wonder about in regard to the BBB. Just after my 2nd or 3rd dose of CAF, I was sitting at the computer and felt a fluid wave move from the base of the neck up through and over the head, and for about 3 full minutes I was entirely blind. I had my eyes wide open, trying to look at the computer screen, but all I was seeing was nothing. It never happened again during the remaining CAF treatments. It was very difficult for me to go ahead with treatment because no one could explain it. I asked my providers about it and no one had any explanation for it. I will always wonder if the blindness was due to something crossing the BBB. I can see from the list that C and F do cross and A does not, and I wonder what caused the blindness. I wonder if there is a difference in my brain tissue compared to others because of that experience, and if there is any difference among patients as to which drugs cross the BBB.
AlaskaAngel
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03-14-2008, 09:41 PM
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#3
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Senior Member
Join Date: Sep 2005
Location: South Dakota.
Posts: 621
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I also wondered when this list was made and I looked for the date before I posted it. But I figured that the (drug) information would not have changed, even if it the post is not real current.
In regards to the "F" in CAF, it says that it has good tissue penetration and crosses the BBB, which surprised me, as I thought my onc told me that it does not cross the BBB. If it does cross, that could be an explaination for your brief period of blindness during treatment.
__________________
Blessings and Peace,
Barbara
DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.
Accepting the gift of life, I give thanks for it and live it in fullness.
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03-15-2008, 12:15 AM
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#4
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Senior Member
Join Date: Mar 2006
Posts: 4,778
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the website you referred to is from a college of veterinary medicine
and seems to refer to the pharmacology/study of drugs in animals
here is the website:
http://cpharm.vetmed.vt.edu/
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03-15-2008, 04:48 PM
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#5
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Senior Member
Join Date: Sep 2005
Location: South Dakota.
Posts: 621
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This chemotherapy is not for the human animal!
You are right, Lani, and I just did some more checking. I had noticed the words on the website, but rationalized that all of those cancer drugs/animals didn't add up; and the website was prefaced by "clinical pharmacology of specific cancer chemotherapy" which led me in the wrong direction.
Sorry folks!
__________________
Blessings and Peace,
Barbara
DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.
Accepting the gift of life, I give thanks for it and live it in fullness.
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03-15-2008, 08:43 PM
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#6
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Senior Member
Join Date: Sep 2005
Location: Alaska
Posts: 2,018
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One site for info
Barbara, this seems like a good reference site, from Ontario, Canada. I note that one drug I found here was updated as of 9/07.
http://www.cancercare.on.ca/index_dr...monographs.htm
A.A.
P.S. Seems like an appropriate topic today -- I did my first chemo on March 12, 2002.... six YEARS ago... CAF
Last edited by AlaskaAngel; 03-15-2008 at 08:46 PM..
Reason: To add PS
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03-16-2008, 09:03 AM
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#7
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Senior Member
Join Date: Jul 2005
Location: Ft. Collins, Colorado
Posts: 546
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thanks you guys
i love this kind of stuff-it is like crack for the information junkie!
__________________
with love and gratitude,
joy
dx stage I 2/2000*er/pr+; her- per IHC*lumpectomy*4 rounds A/C*30 rads*tamoxifen*dx stage 4 5/2002*huge mets to liver*tiny mets to lungs*stopped tamoxifen*5/02 taxotere/xeloda*her 2 checked with FiSH-her2+++herceptin *2/03 stopped chemo femara w/herceptin*zolodex*04 switched to aromasin w/herceptin*05 high estrogen tx*11/05taxol/carbo*7/06 stopped chemo; megace/herceptin*9/06navelbine/herceptin*5/07tykerb/xeloda great response*4/08 progression in liver; ooph/ faslodex /herceptin
6/08 began Herceptin DM-1
9/08 progression
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03-16-2008, 02:32 PM
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#8
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Senior Member
Join Date: Sep 2005
Location: South Dakota.
Posts: 621
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AlaskaAngel, that was a very good site and I bookmarked it. I checked on the Flourouracil and yes, it does cross the BBB. Good news, but I don't think that drug is used much any more.
Thanks for the assist!
__________________
Blessings and Peace,
Barbara
DX Oct 02 @ age 52 Stage 2B Grade 3 Mastectomy
"at least" 4.5 cm IDC 1+node ER+61% /PR-
Assiciated Intraductual component with Comedo Necrosis
Her2+ FISH8.6 IHC 2+
5 1/2 CEF Arimidex
Celebrex 400mg daily for 13 months
Prophylactic mastectomy
Estradiol #: 13
PTEN positive, "late" Herceptin (26 months after chemo)
Oct 05: Actonel for osteopenia from Arimidex.
May 08: Replaced Actonel with Zometa . Taking every 6
months.
Accepting the gift of life, I give thanks for it and live it in fullness.
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