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Old 02-11-2008, 11:46 AM   #1
Kim in CA
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Chrisy,

You sure have been on my mind lately. I know all too well what it feels like to know those nasty "C" cells are running amok in your body and anxiously waiting to start an armed offensive. I am keeping you in my prayers and sending you some very positive thoughts.

You Go Girl! Kim
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Diag. Feb 1997 4.5cm IDC <10%ER+, PR-. 5 out of 36 nodes +. Mastectomy followed by 3 rounds Adriamycin/Cytoxin.


5/1997 Hi Dose Chemo w/ Stem cell rescue. Spent 4 weeks in isolation ward. Then 6 weeks radiation.

9/2001 widespread mets to liver. 8 mos Taxotere/Herceptin brought me almost to NED. Stop Taxotere & add Femara .

11/2002 liver resection to remove spot that turned out to be necrosis. Officially NED!

7/2003 Tumor markers rising add Xeloda Disastrous reaction, 8 days hospital, but tumor markers came back to normal!

June -Dec 2004 UW Vaccine Trial.

7/2005 MRI single 11mm brain met
8/2005 Gamma Knife.

Brain MRI @3 months NED!

2006-2011 brain/body still NED

8/04/11 Taking Herceptin break, will monitor with tumor markers.

6/20/12 Tumor markers begin to rise. CA15-3 is 31.3 and Her2 Serum is at 17.1 Decide to repeat in one month.

7/23/12 CA15-3 now 49.3
Her2 Serum 26.8

8/6/12 Back on Herceptin
CA15-3 now 76
Her2 Serum now 49

11/7/12 Add weekly Taxotere for 4 cycles

2/2013 Stopped Taxotere added Perjeta. MRI shows approx. 50% reduction liver mets. CA15-3 still elevated @ 55. Will continue on just Herceptin & Perjeta.

November 2014 Continuing on Herceptin, Perjeta, and
Femara indefinitely. Guess I'm NED again, but watching those tumor markers carefully!

Dec. 2015 PET scan reveals mass in perirectal area of abdomen.biopsy confirms. Still Her2+, but no longer ER+. Bye bye Femara

Jan 2016 Begin Kadcyla

March 2016 PET scan shows tumor now barely visible, still NED everywhere else.
2016/2017 continue Kadcyla

November 2017 brain MRI reveals small focus of T2 hyperintensity with possible 4mm enhancing nodule. Short term follow up MRI suggested. Stay tuned...
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Old 02-11-2008, 11:58 AM   #2
chrisy
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Location: Central Coast, CA
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first infusion play-by-play

OK, I'm bored, except for every 15 minutes when they have to take my vitals. So far I am still breathing and, except for the time when I had just gotten back from running to the bathroom, my B/P is nice and low. Some change from the Avastin days, plus I think taking the train as I did this morning is a LOT less stressful even tho I had to get up while it was still dark.

The stinging has stopped, after running more saline with the infusion and putting a warm pack on the infusion site for a few minutes. Had me a bit worried because I REALLY want this drug to work, and It probably won't work as well if I'm only looking at it and not actually getting it in my veins.

My hubby is coming to sit with me for this first infusion, since I wasn't sure how I would feel and plus, it's a really long day (90 min infusion followed by 90 minutes of observation then a blood draw 2 1/2 hours after that!). He should be here soon, so I can stop boring you with endless drivel about my treatment!

Somebody stop me!!!!!!
I just took my own temperature and oxygen saturation rate, but the time they let me out of here I'll be accessing my own veins for infusion!
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial

5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure

Last edited by chrisy; 02-11-2008 at 12:08 PM..
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Old 02-11-2008, 03:32 PM   #3
runtolive
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congrats on the first dose.. your are doing every 3 weeks .. correct.. 3.6mg/kg

the good news is the little buggers got nowhere to hide now.. cancer-away.. be gone..

run to live..
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Old 02-12-2008, 04:24 PM   #4
runtolive
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hey chrisy .. how is day 2 on the road to NED.... hope u feel good..

run to live
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