Stem cells: root cause of all cancers & of resitance to all chemos?

[StephN]

This is all SO interesting.
As a survivor who had a favorable outcome so far with Taxol combined with Navelbine and Herceptin, I often wonder what went right with me.

To quote from the last post:
"Even before the advent of the CellSearch technique, it had been observed in "cell death" cell culture assays, that there was an increase in the number of metabolic activity of mitochondria of the surviving cells from Taxol therapy, even in cases where the majority of the cells are being killed by Taxol. It may indeed give clinical response (tumor shrinkage), however, these are mostly short-lived and relapses after a response are often dramatic. "

The chemo combo I was on was part of a trial dubbed "Antimitotic," since each drug killed the cells at a different phase of division. If a cell as missed by one drug, there was a good chance the other drug would catch it. Seemed to be a good theory, but I know there is more to it than that.

Glad I have not followed the curve and "lapsed."

[gdpawel]

As one of the editors of the Journal of Medicinal Food, Dr. Robert Nagourney, Medical Director at Rational Therapeutics, Inc., in Long Beach, California and an instructor of Pharmacology at the University of California, Irvine School of Medicine, he was asked to review an article on the chemical activities of grape seed extracts. He wrote an editorial describing the interesting findings in this study and their biological relevance.

For many years, naturopaths and health-conscious individuals have recommended the consumption of grape seed extracts. Chemical analyses of grape seeds have provided a treasure trove of active ingredients including resveratrol, anthocyanins, pro-anthocyanins, and numerous terpenes. Many of these substances are potent antioxidants and there is reason to believe that they may have meaningful health benefits.

The most interesting aspect of this well-conducted analysis was the description of a wholly new mechanism of action for the substances found in grape seeds. What the authors found was that the chemical species in grape seed extracts influence gene expression through a process knows as histone acetylation. What makes this so interesting is the fact the histone acetylation is one of the fundamental regulators of genetic expression and a critical part of the new field of science known as epigenetics.

Epigenetics is the field of study that examines heritable attributes that are not incorporated into DNA sequence. These epi-phenomena take existing genes and determine whether or not they will actually be expressed. The reason that this is so important is that it shines a very bright light on the limitations of genomic analyses (studies that examine the DNA sequence in tissues). Clearly, if the consumption of foodstuffs (like grape seed) can alter gene expression then the use of genomic profiles to predict cellular behavior can only be viewed as highly simplistic.

Dr. Nagourney is continually impressed by the complexity of biology and is humbled when we consider the intersecting pathways that take us from gene to function.

http://www.liebertonline.com/doi/abs.../jmf.2010.9401