British Journal of Cancer (2006) 94, 346-350.
doi:10.1038/sj.bjc.6602942 Published online 17 January 2006
COX inhibitors and breast cancer
D Mazhar1, R Ang1 and J Waxman1
1Department of Cancer Medicine, Division of Medicine, Faculty of Medicine, Imperial College London, Room 1014 Garry Weston Centre, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
http://www.nature.com/bjc/journal/v9.../6602942a.html
" Minireview
British Journal of Cancer (2006) 94, 346-350.
doi:10.1038/sj.bjc.6602942 Published online 17 January 2006
COX inhibitors and breast cancer
D Mazhar1, R Ang1 and J Waxman1
1Department of Cancer Medicine, Division of Medicine, Faculty of Medicine, Imperial College London, Room 1014 Garry Weston Centre, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
Correspondence to: Professor J Waxman, E-mail:
j.waxman@imperial.ac.uk
Received 3 October 2005; revised 6 December 2005; accepted 6 December 2005; published online 17 January 2006
"There is considerable evidence to suggest that prostaglandins play an important role in the development and growth of cancer. The enzyme cyclo-oxygenase (COX) catalyses the conversion of arachidonic acid to prostaglandins. In recent years, there has been interest in a possible role for COX inhibitors in the prevention and treatment of malignancy."