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Old 09-13-2007, 03:36 PM   #1
cafe1084
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Yes, it is safe to have taxol and H on the same day. I actually had T and H together for 12 weeks and was fine as long as they ran each one separately and slowly. Otherwise, I had horrible heartburn, a metallic taste in my mouth, and nausea

The only side fx I've had from H is still the metallic taste in my mouth if ran too quickly and I have kept a sinus infection since I started it. I have a dry cough i never had before and my blood pressure still hasn't returned to pre-cancer normal, but my heart is fine. I am sure there are others who've experienced different side effects, though.

As far as surgery, I have read that it is completely safe and being on H during surgery is an added benefit because if there are other cancer cells that get "activated" or stirred up during surgery, H will target these.

It's always scary starting new meds, never knowing what to expect, so I wish you the best of luck!!

steph C
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Old 09-13-2007, 04:19 PM   #2
Lolly
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Hi Kim;
In my experience it's been fine to be on Herceptin and taxanes together. Currently I'm on Taxotere and Herceptin and get them both on the same day.

Your onc should order an Echo or MUGA scan of your heart soon,to use as a baseline measure. This should be repeated throughout your course of Herceptin. Some oncs run the scan every 3 months, some every 6 months.

I had a mastectomy while on Herceptin, and did fine. I know several others on this board have had various surgeries while on Herceptin and had no problems, so you should be fine, although I would hope your onc would order the heart scan at some point before your surgery just to make sure you're fine.

Welcome to the board

<3 Lolly
__________________
Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.

Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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Old 09-13-2007, 08:59 PM   #3
tousled1
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Welcome to the board. Yes you can have Herceptin and Taxol at the same time. I'm currently getting Herceptin, Taxol and Carboplatin. Just make sure that your oncologist orders either an echocardiogram or MUGA and that you have them repeated every 3 months while on Herceptin. Herceptin can reduce your LVEF (left ventricular ejection factor). If it drops to 50% or below Herceptin would have to be stopped.
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Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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