After further research on PPAR, I realized it has major role in tissue repair and controlling inflammation at the same time PPAR oddly increase the 3PIK pathway and represses pTEN, which would seem to increase the inflammatory her2 pathway.
'PPARs are major regulators of lipid, glucose, and amino acid
metabolism. Here we have presented some of their less well known
functions in tissue protection and repair. A majority of the
studies reviewed herein are descriptive, and even the use of
specific ligands does not necessarily distinguish between PPAR
isotypes or between PPAR-dependent and -independent mechanisms.
However, collectively, the studies have improved our understanding
of the role of PPARs in healing. Their actions are simultaneously
systemic and cellular. Systemic effects are antiinflammatory,
antioxidant, and metabolic, such as the normalization of circulating
lipids and insulin resistance. During the early postinjury inflammatory
phase, lipoxygenases and cyclooxygenases stimulate production
of PPAR ligands. Indeed, perhaps the most striking action of
PPARs is the control of inflammation, an event first observed
10 years ago (
119). Inhibition of the NF-
B pathway appears to
be central to this process."
"Together,
these results suggest that the PPAR
and PPAR
agonists already
used in clinics may be harnessed for angiogenic diseases.
"
Quotes from:
http://www.jci.org/cgi/content/full/116/3/598?ck=nck
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