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Old 06-15-2007, 10:29 PM   #1
JEANB
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Join Date: Mar 2007
Location: Indpls, IN
Posts: 12
Thumbs up Good news with Tykerb

Hi you guys, I just wanted to share my good news with the Tykerb/Xeloda drug combo. A little history ...I became stage 4 last July with extensive liver mets over 70%..My tumor marker Ca 27/29 was 1149,,my bile duct was completely obstructed and I became jaundice, had terrible itching, lost weight, etc..this occurred rapidly, over a 3 week period. At first, my bilirubin was too high to get chemo, topped out at 9.3. We tried liver stents several times and I even had to have a drainage tube inserted into my gallbladder to drain out bile. I carried around a drain bag for 3 months.This worked and I was able to get Gemzar/Herceptin which eventually brought my markers down to 80. My markers started to increase in March and went up to 123 at last check 5 weeks ago.
I started Tykerb (5 pills 1250) and Xeloda (7 pills 3500mg) just 4 weeks ago. My tumor marker has dropped 50 points..I'm at 73 now, lower than ever.I'm so happy with this drug combo!! I did have some severe dryness however, (face peeling and so thirsty) a slight rash and I got the diarrhea which is unusual for me. My doc lowered my Tykerb by one pill so we will see how that goes.
Rock on Tykerb..love these results!!

JB
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Jean B

Inflammatory Breast Cancer 2003
A/C Taxol dose dense regimen
6 weeks radiation
1 year Herceptin
NED for 2 years and 4 months
Recurrence in July 2006 with extensive liver mets over 70%, tumor obstructing bile duct-gallbladder, mets to spine and pelvis, abdominal lymph nodes enlarged, mass on pancreas.
Hospice called in until Gemzar and Herceptin started in Aug. 2006
May 2007 pet scan shows only 1 liver lesion 1.1 cm. bone mets gone, no enlarged lymph nodes.
June 2007-Switch to Tykerb/Xeloda because markers increased
Sept 2007-tumor marker 357-2.4 cm mass on pancreas,1 cm lesion on thyroid, duodenum and more liver mets.--switch to abraxane/carboplatin/herceptin and doing much better
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Old 06-16-2007, 12:41 AM   #2
hutchibk
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My TMs have dropped from 45.1 to 37.5 to 17.5 after only 6 weeks on Xeloda and 4.5 weeks on Tykerb!! And my brain MRI is stable with one of the bigger spots looking less enhanced...

I am loving it too!
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Brenda

NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."
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