So, is this saying that there might be a preliminary implication that ER+ bc cell lines (MCF-7) and a Her2+ cell line are sensitive to taxanes. This would make sense (even though the Her2+ line here is also ER/PR -) as there was a real study on node positive bc using taxol (real women) presented at San Antonio that showed that using taxol greatly reduces the chance of recurrence in Her2+ women REGARDLESS of hormone status.
However, the same study showed that taxanes do relatively nothing to node positive women who are only hormone positive and not Her2+ as well. However, MCF-7 is a line that is sensitive to alpha and beta estrogens (and many Her2+ women who are hormone positive tend to be beta+ so.... that may be the responsive part of this cell line.
This is a great article Lani. Thanks for posting it as it has held true to form in a real life study.
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Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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