for those with brain mets (and those scared of developing brain metastases)

[heblaj01]

In checking the pharmacokinetics of Boswellia Serrata I found this article which describes it as an iinhibitor of P450 enzymes which are required in the liver to metabolize some chemo drugs such as Navelbine.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=163643 38&dopt=Abstract
Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction.
The abstract does not state if the inhibition is occuring only in he gut or in the liver or both.
If the inhibition is restricted to the gut then intravenous chemo drugs would not be affected.
If however the inhibition is in the liver the consequences could be lowered effectiveness of the chemo treatment & possibly higher level of side effects due to longer persitance of the drug in the body & higher accumulation.

I hope this will turn out to be a false alert for most of those planing to use Boswellia but it needs to be clarified by someone with the right background such as Lani.

[Vanessa]

Hi Lani,

Thanks for the great information!

[R.B.]

Glad to see this resurface.

Re my post above.

Please do have a look at the omega three six posts if you have time or are tempted.

The essential fats and particularly omega three play a key part in brain health.

There have been suggestions that higher threes and lower sixes in the brain tissue are associated with lower risk of some brain cancers.

RB