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Recurrence for ER+/PR-/HER-2+ tumors
Hi fellow HER-2ers,
Does anyone know about the recurrence behavior of ER+/PR-/HER-2+ tumors? In particular, does recurrence peak at 2 years post surgery/diagnosis or does it also peak at 6 years after Tamoxifen/AI treatment? And does the fact that PR is negative while ER is positive affect the tumor response to hormonal therapy? Are there any studies that have looked at this subtype and how does it compare to the triple-positive, the ER-/PR+/HER-2+ tumors or the ER-/PR-/HER-2+ ones?
I've read some papers that talk about the role of the PR receptor, but nothing yet on how it affects recurrence rates for the ER+/HER-2+ cases. It seems to be a rarer subtype, but I do know that there are several of us with it here.
Any ideas? Who is doing research on the PR receptor and its role around the country?
Thanks!!!
Marcia
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ER+ (30%)/PR-/HER-2+, stage 3
Diagnosed on 02/18/09 at 38 with a huge 12x10 cm tumor, after a 6 month delay. Told I was too young and had no risk factors. Found swollen node during breastfeeding.
March-August 09: neo-adjuvant chemo, part of a trial at Stanford (4 DD A/C, 4 Taxotere with daily Tykerb), loading dose of Herceptin
08/12/09 - bye bye boobies (bilateral mastectomy)
08/24/09 - path report shows 100 % success in breast tissue (no cancer there, yay!), 98 % success in lymphatic invasion, and even though 11/13 nodes were still positive, > 95 % of the tumor in them was killed. Hoping for the best!
September-October 09: rads with daily Xeloda
02/25/10 - Cholecystectomy
05/27/10 - Bone scan clear
06/14/10 - CT scan clear, ovarian cyst found
07/27/10 - Done with Herceptin!
02/15/11 - MVA-BN HER-2 vaccine trial
03/15/11 - First CA 15-3: 12.7 and normal, yay!
10/01/11 - Bone scan and CT scan clear, fatty liver found
now on Tamoxifen and Aspirin
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