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Lani;
I am HER-2/neu borderline/FISH positive and am curious about what you think this study means. When stated that my group shows "significant differences with multiple parameters" I am confused.
I have read an interesting article which discussed a study done on RNA samples of 360 primary breast cancer tumors where probes for 160 distinct genes in the 17Q chromosomal region were arrayed in the order of their location along the chromosome. These tumors with similar patterns of gene expression, including elevated her2 expression were clustered together by a computer and grouped. In the array of genes where her2 RNA was elevated expression of closely linked genes mapping to both sides of the gene was also elevated. "This reflects the fact that the unit of DNA amplification -- the amplicon -- almost always included a stretch of chromosomal DNA that was far longer than the erbB2/neu/HER2 gene itself., leading to co-amplification of these neighboring genes. Among these genes are several that may also psoitvely influence cell proliferation and survival, including GRB7 and PPARB whose protein products interact with ErbB2 and with the apoptosis cicuitry, respectively. Hence, in such cases, a number of co-amplified genes may be collaborating to orchestrate the malignant phenotype of human breast cancer cells, and it becomes difficult to ascribe specific cancer cell phenotypes to the elevated expression of only a single gene, such as erbB2/neu/HER2."
I wonder if Her2 borderlines are not tumors whose genes express more of these borderline/neighboring genes ....such as GRB7 or PPARB than erbB2 in fact. This, to me, suggests that for us borderlines, perhaps other treatments might be more effective.....I wonder about lapatinib?
Cathy
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Cathy
Diagnosed Oct. 2004 3 cm ductal, lumpectomy Nov. 2004
Diagnosed Jan. 2005 tumor in supraclavicular node
Stage 3c, Grade 3, ER/PR+, Her2++
4 AC, 4 Taxol, Radiation, Arimidex, Actonel
Herceptin for 9 months until Muga dropped and heart enlarged
Restarting herceptin weekly after 4 months off
Stopped herceptin after four weekly treatments....score dropped to 41
Finished 6 years Arimidex
May 2015 diagnosed with ovarian cancer
Stage 1C
started 6 treatments of carboplatin/taxol
Genetic testing show BRCA1 VUS
Nice! My hair came back really curly. Hope it lasts lol. Well it didn't but I liked it so I'm now a perm lady
29 March 2018 Lung biopsy following chest CT showing tumours in pleura of left lung, waiting for results to the question bc or ovarian
April 20, 2018 BC mets confirmed, ER/PR+ now Her2-
Questions about the possibility of ovarian spread and mets to bones so will be tested and monitored for these.
To begin new drug Palbociclib (Ibrance) along with Letrozole May, 2018.
Genetic testing of ovarian tumour and this new lung met will take months.
To see geneticist to be retested for BRCA this week....still BRCA VUS
CA125 has declined from 359 to 12 as of Aug.23/18
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