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03-06-2008, 08:03 PM
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#21
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Senior Member
Join Date: Oct 2007
Posts: 1,851
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Hi Catherine,
In general, chemotherapy cuts the risk of recurrence by 30%. That is, if your initial risk based on your stage, number of positive lymph nodes, etc. is 20%, for example, then chemotherapy cuts the risk by 6%, making the risk 14%. I think that Herceptin would then cut that risk by roughly 50% to approximately 7%.
Joan
__________________
Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2023 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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03-06-2008, 09:51 PM
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#22
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Senior Member
Join Date: Jan 2008
Posts: 305
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Quote:
Hi Catherine,
In general, chemotherapy cuts the risk of recurrence by 30%. That is, if your initial risk based on your stage, number of positive lymph nodes, etc. is 20%, for example, then chemotherapy cuts the risk by 6%, making the risk 14%. I think that Herceptin would then cut that risk by roughly 50% to approximately 7%.
Joan
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Is there anywhere on the web where they say what the chances of recurrence are - with or without chemo and radiation? I have found stats by stage but I have never seen it listed as to the difference with or without chemo and or radiation. |
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03-06-2008, 11:44 PM
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#23
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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First of all ...... Welcome Back Becky!!! So happy your are back on board!!
Goops, in regards to your question about where to find a recurrance score. Adjuvant.com is the place where you can find a recurrance score. In fact Dr. Pegram gave me 2 printout results, one which included the HER2neu and one without. It definitely helped me make that decision to do the chemol
Maryanne
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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03-06-2008, 11:57 PM
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#24
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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For Becky
Becky, I hope your buddy comes back soon too because she is also very much missed.......
Maryanne
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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03-07-2008, 06:05 AM
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#25
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Senior Member
Join Date: Jan 2008
Posts: 305
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Thank you Harrie - I will check it out!
I got some type of a financial place - could you please repost the link Harrie. Thanks
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03-07-2008, 12:08 PM
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#26
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Senior Member
Join Date: Nov 2004
Location: Misty woods of WA State
Posts: 4,128
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Hi Harrie -
Sorry to point out that those posts from Becky are from one year ago.
She even took her pic off and put the hamster's.
Maybe she is training for a marathon?
__________________
"When I hear music, I fear no danger. I am invulnerable. I see no foe. I am related to the earliest times, and to the latest." H.D. Thoreau
Live in the moment.
MY STORY SO FAR ~~~~
Found suspicious lump 9/2000
Lumpectomy, then node dissection and port placement
Stage IIB, 8 pos nodes of 18, Grade 3, ER & PR -
Adriamycin 12 weekly, taxotere 4 rounds
36 rads - very little burning
3 mos after rads liver full of tumors, Stage IV Jan 2002, one spot on sternum
Weekly Taxol, Navelbine, Herceptin for 27 rounds to NED!
2003 & 2004 no active disease - 3 weekly Herceptin + Zometa
Jan 2005 two mets to brain - Gamma Knife on Jan 18
All clear until treated cerebellum spot showing activity on Jan 2006 brain MRI & brain PET
Brain surgery on Feb 9, 2006 - no cancer, 100% radiation necrosis - tumor was still dying
Continue as NED while on Herceptin & quarterly Zometa
Fall-2006 - off Zometa - watching one small brain spot (scar?)
2007 - spot/scar in brain stable - finished anticoagulation therapy for clot along my port-a-catheter - 3 angioplasties to unblock vena cava
2008 - Brain and body still NED! Port removed and scans in Dec.
Dec 2008 - stop Herceptin - Vaccine Trial at U of W begun in Oct. of 2011
STILL NED everywhere in Feb 2014 - on wing & prayer
7/14 - Started twice yearly Zometa for my bones
Jan. 2015 checkup still shows NED
2015 Neuropathy in feet - otherwise all OK - still NED.
Same news for 2016 and all of 2017.
Nov of 2017 - had small skin cancer removed from my face. Will have Zometa end of Jan. 2018.
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03-07-2008, 01:18 PM
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#27
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Senior Member
Join Date: Aug 2006
Posts: 3,380
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Goops, I think it is adjuvantonline.com
Hopeful
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