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11-06-2006, 07:17 AM
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#21
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Senior Member
Join Date: May 2006
Location: northshore suburb of chicago
Posts: 1,093
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Genentech, Inc.
1 DNA Way
South San Francisco, CA 94080-4990
Phone: 1-650-225-1000
Fax: 1-650-225-6000
__________________
~Rina~
Dx:3/06 had a lumpectomy April 19, 2006
Her2+ er/pr- Stage I Grade 3 tumor size 1.4 cm, node negative
AC 4 dense doses
34 radiation treatments including booster doses
receiving herceptin every 3 weeks since late August 2006 for 12 months
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11-06-2006, 01:56 PM
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#22
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Senior Member
Join Date: Jun 2006
Location: Central North Carolina, USA
Posts: 112
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I was able to find contact information for Genentech on the web and I emailed them and they called me already and opened a file. They did say that Herceptin is not FDA approved for early stage breast cancer and they do not have any incidents of prolonged hypertension. They thanked me for contacting them and asked that I call them and let them know my blood pressure before and after tomorrows treatment. I’ll let you all know.
__________________
DX 11/14/05, Stage 1C, Her2+ 3.4, ER+, PR+, K167 23%, Node Negative, MX0, Grade 3, 1.8CM, Lumpectomy 12/7/05; 6 rounds dense dose Taxol bi-weekly, 35 radiation, 1 year Herceptin, & Tamoxifen ongoing.
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11-06-2006, 02:03 PM
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#23
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Senior Member
Join Date: May 2006
Location: northshore suburb of chicago
Posts: 1,093
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Thank you for contacting them. Perhaps I should call as well because the more calls they get on this then maybe they will realize that there are those getting elevated pressures from herceptin. Would you mind posting the contact you have?
__________________
~Rina~
Dx:3/06 had a lumpectomy April 19, 2006
Her2+ er/pr- Stage I Grade 3 tumor size 1.4 cm, node negative
AC 4 dense doses
34 radiation treatments including booster doses
receiving herceptin every 3 weeks since late August 2006 for 12 months
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11-07-2006, 05:11 AM
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#24
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Senior Member
Join Date: Jun 2006
Location: Central North Carolina, USA
Posts: 112
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Genentech Contact information
__________________
DX 11/14/05, Stage 1C, Her2+ 3.4, ER+, PR+, K167 23%, Node Negative, MX0, Grade 3, 1.8CM, Lumpectomy 12/7/05; 6 rounds dense dose Taxol bi-weekly, 35 radiation, 1 year Herceptin, & Tamoxifen ongoing.
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11-08-2006, 01:59 PM
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#25
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Senior Member
Join Date: Jun 2006
Location: Central North Carolina, USA
Posts: 112
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Well, I had my second MUGA yesterday and my left ventricle ejection is 65%. That is actually an improvement over my last MUGA in December of 2005. My blood pressure was also lower than my last Herceptin treatment. I was worried because it was 150 over 75 3 weeks ago but yesterday it was 132 over 72.
__________________
DX 11/14/05, Stage 1C, Her2+ 3.4, ER+, PR+, K167 23%, Node Negative, MX0, Grade 3, 1.8CM, Lumpectomy 12/7/05; 6 rounds dense dose Taxol bi-weekly, 35 radiation, 1 year Herceptin, & Tamoxifen ongoing.
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11-08-2006, 09:09 PM
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#26
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Senior Member
Join Date: Dec 2005
Location: Alexandria, VA
Posts: 1,055
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In the Wa Post today they reported people with a higher top number were less likely to have CHF. For what it's worth. BB
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03-01-2007, 12:04 PM
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#27
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Senior Member
Join Date: Jun 2006
Location: Bradenton,FL
Posts: 977
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I am joining the " hypertension club". My last few BPs (using calf cuff reading) have been anywhere from 150 to 180 ! During TX w Hercep I occaisionally had high readings, butsince I have have had consistently high readings the last 4 months or so, I am now on Zestril.
Havent taken my first one ...YET... but am so sorry to have to add yet another medication to my routine.
Marcia
PS Hypertension has affected all the men on my fathers side of the family...most died from CAD.My weight is 150 and I am 5' 5 1/2...cholesterol levels arent so hot either. DARN! I may just have to go out and buy one of those BIG plastic med- minders!! LOL
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03-01-2007, 12:37 PM
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#28
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Senior Member
Join Date: Aug 2003
Location: Morris, IL
Posts: 3,507
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Also an update for me....my B/P is almost consistent now in the 150-155 over 78 range....it was always in the 110/60 range....I am only on the Herceptin now, off Xeloda for the time....it seemed like it was back and forth and now is staying high...my echo 2 months ago said the LVEF was 60%
I am keeping tabs on it as my Mother has high B/P/
__________________
"Be kinder than necessary, for everyone you meet is fighting some kind of battle."
Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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03-01-2007, 01:02 PM
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#29
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Senior Member
Join Date: Oct 2005
Location: TN
Posts: 84
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This is interesting! My BP has gone up dramatically while on Heceptin. My MUGGA is great! I have also been having headaches, though, and am getting another MRI tomorrow, before seeing about BP meds. I have been on Herceptin since Aug 2003.
__________________
3/2003-Dx'd Stage 4 Her 2+++
"Life is not measured by the number of breaths we take, but by the moments that take our breath away."
Dum spiro spero (Latin: while I breathe I hope)
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03-04-2007, 08:37 PM
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#30
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Senior Member
Join Date: Nov 2006
Location: West Virginia
Posts: 105
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Just had my 5th taxol/herceptin Friday and no problems ...til today. BP has been high since my first AC tx back in November, running about 140/90 compared to my norm 130/80. I got up this morning with the most horrible headache and neck pain(lingering headache for 2 days or so). Didn't realize til late afternoon that my neck veins felt as if they could pop, then the nausea and blurred vision hit. Long story short, my mom checked my BP and it was 170/110! Not only did I have a headache to kill a cow, I was in sheer panic over those numbers. I've had no real side effects with these tx's, BUT my taxol and herceptin were ran concurrently instead of separately as they had in the first 4 previous tx's. This time, heartburn like my tummy was on fire, some nausea, and this headache! I wouldn't think this would matter so much, may not be wise for the sake of determining the culprit if I were to have a reaction, but shouldn't cause such a great change in how I feel after tx, unless this is just from meds building up in my system. Anyone had this or know why or if the meds ran together would cause an immediate change? For now, have a good supply of diuretics and some Mrs. Dash no salt substitute !
Steph C
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03-05-2007, 10:17 AM
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#31
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Senior Member
Join Date: Sep 2006
Location: Houston, Texas
Posts: 624
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My blood pressure and heart rate are both up a bit. I am having an echo in the next two weeks, just waiting for the nurse to call me with an appointment time.
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03-05-2007, 05:14 PM
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#32
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Senior Member
Join Date: Feb 2007
Location: Nova Scotia, Canada
Posts: 40
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This is my first post but I wanted to thank you all for this thread, I thought I had lost my mind, not that I remember if I had one LOL. I always had low blood pressure and had to be careful when bending down that I didn't pass out when I stood up, but during my last treatment of Herceptin my BP was 121/91 and heart rate was 122........ I am seeing my GP tomorrow and having the BP checked. I have also gained weight, probably 20 lbs in the last six months. Thank you, thank you....... I am thankful that I found this site and all you great ladies.
Thanks Patricia
__________________
Intial Dx Sept3,2002, age 39
Masct/ Sentinel Node Biopsy Sept 11,2002 node negative
ER/PR- Her2+++, grade 3
Started AC Chemo Nov 2002, 4 rds
2003 NED
May 2004 reconstuction, saline and later silicone implant
Aug 2006 Dx recurrence, lymph nodes chest/lungs/sternum
Dec 2006 Herceptin q three weeks
May 2007 bone mets to sternum
June 2007 aredia for bone mets
June 2007 radiation to sternum X 5
June 2008 slow progression of lung met, all other mets NED, continue Herceptin, Aredia, add Xeloda
July 08 Stopped Xeloda, severe side effects from the drug, but it did a fantastic job after only 12 days at least 50% reduction
Feb 09 Started Navelbine with herceptin, slight progression in lungs.
July 09 - Nov 09 had a Navelbine holiday...
Nov 09 back to Navelbine, Herception
Feb 10, lungs have improved but 4 small lesions on liver, started Taxol, Herceptin....
Taxol not the magic drug for me
Continuing Herceptin,Aredia,and adding Xeloda once again..reduced dose
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04-01-2007, 09:33 AM
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#33
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Senior Member
Join Date: Jun 2006
Location: Bradenton,FL
Posts: 977
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Derar Friends,
Just had my one month check up to see if my pressure meds did the trick. I was shocked by the Nurse saying "Whoa"! still high 165/85. New RX :Micardis HCT, appointment in 4 weeks and we will see if it worked.
Funny, I always ass u med (LOL) if your pressure is high that one would have energy.Boy was I wrong..all I do is sleep and work! ARGH
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04-03-2007, 09:12 AM
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#34
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Senior Member
Join Date: Jun 2006
Location: Bradenton,FL
Posts: 977
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Hi there friends, Micardis caused severe depression and insomnia...back to the drawing boards. No meds thios week and will see how I do without them.
Marcia
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04-03-2007, 10:30 AM
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#35
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Guest
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I've had high blood pressure for years, long before herceptin and chemo. It seems to be holding steady, not going up or coming down. Over the years my medication has been changed many times until we found something that works. The one that works very well for me is Lotensin/HCT. The HCT is a diurectic. Everyone responds differently to BP meds, but you'll find one that works for you, I'm sure.
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04-03-2007, 01:30 PM
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#36
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Senior Member
Join Date: Jun 2006
Location: Bradenton,FL
Posts: 977
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THX Grace for the reassurance. I needed it!
Warmly,Marcia
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04-03-2007, 01:49 PM
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#37
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Senior Member
Join Date: Jun 2006
Location: Oklahoma
Posts: 39
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Erratic BP
I had high bp before all this and was on Micardis/hct & Norvasc. My Onc said my echo is low 44% and my blood pressure is also erratic, sometimes high, sometimes low. He took me off Herceptin for awhile and sent me to a cardiologist who put me on Coreg & HCT. Now I have to weigh twice a day and take my bp twice a day for fluctuations. I've only done it a few days so don't see anything really surprising. I hope I can get back on herceptin soon.
__________________
Ora
_____________
DX 7-5-05, Age 54, Stage 1, Grade 2, ER+ (25%) PR- Her2 neu 3+
Lumpectomy 8-4-05, 2cm tumor, 3 nodes neg, Completed 4 A/C, 4 taxol, decadron (weekly due to steriod reaction) finished 4-17-06
Finished 33 rads 6-5-06, Femara, Started Herceptin 6-22-06
Effexor for hot flashes, Taken off Herceptin Feb 2007 due to low LVEF (44 by Echo) Coreg & Lisinopril replaced bp meds - April Echo back up to 55 Resumed Herceptin 5-21-07.
2010: almost 5 YRS NED!!! Still taking Femara & Coreg. Due to all the CT scans, abdominal aneurysm found & repaired. Something good came out of having cancer.
2013 7+ years NED. Still on Femara
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04-04-2007, 06:34 AM
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#38
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Senior Member
Join Date: Aug 2006
Location: Rowlett, TX
Posts: 138
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This is an interesting discussion. I've taken BP pills (Benicar HCT) for high blood pressure for several years. But, in cycle 5 of my chemo (TCH), I experienced some problems with very low bp. They did a rush MUGA, but it was fine (60%). I'm now off the BP pills and take my BP twice a day. If first number goes above 150, I take a pill (still the Benicar HCT). I've taken only 3 pills since Dec 11 (about 1/month).
I blamed the chemo, but my last one was over 3 months ago. And I STILL have normal BP. Maybe it IS the Herceptin. I never connected that before.
I'm not complaining. It's NICE to be off pills (*smile*).
Janet
__________________
Janet in Rowlett Texas
Dx July 2006 IDC 1.8cm, ER-/PR- HER2+ (FISH 7), KI67 High (60%) grade 3, TOPO II neg
Aug2006: lumpectomy, SNB (4 nodes neg), Stage 1
Jan 2007: Finished 6 cycles of TCH (Taxotere, Carboplatin, Her ceptin). Then Herceptin every 3 weeks.
Feb 2007: Completed Radiation
May 2007: Stopped Herceptin due to low LVEF (49%)
July 2007: LVEF now 44% -- starting Coreg
May 2008: Heart NORMAL! Yippee.
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