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The only correlation between progesterone and Her2 (actually the Her/VEGF pathways) that I have found (to include some of this year's ASCO reports) have to do with the fact that the growth receptor pathways downregulate progesterone (usually far more) than estrogen.
Some of the papers and posters this year focused on the triple negative women but did (in 2 posters and one presentation) reference ER+ but PR neg. I did attend these as it is a rarer pathology of which I have.
Being progesterone negative points to being Her+ (1-3 - at least one of them) and also one may be VEGF positive as well. ER+, PR- tend to be Her2+ (a small population is also Her1+). At least 35% of triple negatives are Her1+. More ER-PR- women who are Her2+ are Her1+ versus those that have at least one hormone receptor being positive. You are absolutely less apt to be Her1+ if you are ER and PR positive.
It seems that the progesterone receptor being positive is associated with a much better prognosis than just being ER+ but I think it is due to the fact that the Estrogen receptor likes to crosstalk more than associate with itself so if there is no progesterone receptor, then other pathways HAVE to be involved. Other papers elude that the other pathways shutdown the progesterone receptor. Very complicated.
Thanks for being so dedicated to the Omega 3/6 balance and information. I swear it is why my cancer was so downgraded as I began doing that about 2-3 months prior to diagnosis and continued throughout treatment. I am a true believer.
Kind regards
Becky
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