Anyone on HERCEPTIN+AROMATASE INHIBITORS?

[R.B.]

More on fats and brains.

This time from the perspective of a search on anorexia.

Key phrase " In patents with acute and chronic inflammatory conditions, low tissue concentrations of omega-3 fatty acids and high concentrations of proinflammatory cytokines are found".

BC is considered by some at least in part to connect to the COX2s inflamatory pathways etc.

RB





1: Curr Opin Clin Nutr Metab Care. 2005 Jul;8(4):403-7. Related Articles, Links
Click here to read
Omega-3 fatty acids and anorexia.

Goncalves CG, Ramos EJ, Suzuki S, Meguid MM.

Surgical Metabolism and Nutrition Laboratory, Department of Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA.

PURPOSE OF REVIEW: To review the mechanisms of action of omega-3 fatty acids and their role in the brain, as well as their therapeutic implications in anorexia. RECENT FINDINGS: Recent studies have demonstrated that omega-3 fatty acids modulate changes in the concentrations and actions of several orexigenic and anorexigenic neuropeptides in the brain, including neuropeptide Y, alpha-melanocyte stimulating hormone and the neurotransmitters serotonin and dopamine. In patients with acute and chronic inflammatory conditions, low tissue concentrations of omega-3 fatty acids and high concentrations of proinflammatory cytokines are found, in association with anorexia and decreased food intake. The data suggest that omega-3 fatty acid supplementation suppresses proinflammatory cytokine production and improves food intake by normalizing hypothalamic orexigenic peptides and neurotransmitters. SUMMARY: Based on current data, omega-3 fatty acid supplementation has a role in the treatment of anorexia by stimulating the production and release of orexigenic neurotransmitters in food intake regulatory nuclei in the hypothalamus.

Publication Types:

* Review


PMID: 15930965 [PubMed - indexed for MEDLINE]