her2 resistance Lani's Post two cents worth

Jean · 04-05-2006, 07:32 AM

Lani,
A big HAPPY BIRTHDAY to you.
Thank you for your speedy response when you are so very busy.
I appreciate your reply so very much.

My Proliferation Index was 40% (I would call this high) would you?
Estrogen Receptor was >90% (also high)
More than 20% tumor cells were actively cycling (in the G1, S, G2 and M phases of the cell cycle),this tumor is considered to have a high index.
Yes, I was node negative.

I am taking Vit. D along with additional vit. I am already taking Aleve
(mostly for the joint pain relief from the Arimidex). Of course I have
enhanced my diet with fish oil, Omega 3 (thanks RB)..olive oil, walnuts,
and organic products as much as possible.

My oncs have said what Dr. Slamon says regarding the cardiac risk is not worth it (since my tumor was small and low grade) but I cannot help but feel so very concerned that all Her2nue cancers are extremely dangerous and fall into a special catagory. My dr. is not and states he would not
consider givering chemo / or / herceptin to me.

Yes Lani, there is a great deal to be learned - I pray it is sooner rather than later. I am now not sure if I made the correct decision regarding Oncotype
test - (once again my onc did not feel that test was worth it) I thought
it would give me some peace of mind if the results were low (my onc thought with my tumor it would be).

Read your post regarding the oncologist with bc. (excellent post).

Lani am I understanding your post correctly when you mentioned that
those who are her2+ have a much higher rate of recurrence (okay understood that) and they are relatively chemo-and hornomal -therapy resistant.
Would you expand on that - I have not heard anything regarding the
her2+ positive being resistant - ex. Arimidex, please explain what that means?

Lani thanks so much again!
Jean

R.B. · 04-05-2006, 01:37 PM

Re omega three six.

From your post diet is part of your strategy. Whilst omega three is widely recognised as benificail at all sorts of levels, it is also important to balance omega three and six intake.

This is still hotly debated territory, but omega six whilst essential is a percusor of many of the inflamatory pathways, and hence it is argued the need to restrict and balance six with threes.

See the posts on this site on omega three , six flaxseed etc.

This can take a little effort to find out how much omega six and three is in various food in general terms. Eg virgin cold pressed olive oil is about 10% omega six, walnuts a lot higher etc, so as a general rule you have to watch how much you take in and add flax etc if you are going to balance the omega threes and sixes.

As usual it is complex and potentially particularly for those on medication. Looking up the NCBI library and using the search engine can be helpful for seeing if any trials of omega three and various medications have been done. It is always best to discuss magor dietary changes with your advisors.

RB