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Robin
I have the downloaded an abstract of an article by Munzone et al in Breast Cancer Research 2006, 8:R4 'Reverting estrogen-receptor-negative phenotype in Her-2-overexpressing advanced breast cancer patients exposed to trastuzumab plus chemotherapy'. It hasn't got a link at the bottom so I can't paste it in. I expect I found it via pub med. This is a very small sample of 10 patients with advanced BC, Her2+ve, ER and PR -ve, who received Herceptin weekly as a monotherapy or combined therapy. 3 of the 10 showed overexpression of er first appearing after 9,12 and 37 weeks.
We are using this to ask for a re-test for my sis who has progressed on herceptin, in case hormonal therapies may become an option for her.
Hope this helps
Sue M
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