IHC +3 - do not need FISH
Hi Rich -
Maybe most docs would want to reconfirm for HER2 by FISH if the IHC was only ++ or less, but if it is +++ by IHC we get Herceptin.
I was HER2+++ by IHC at my diagnosis and have never had the FISH, even for my mets. I have responded well on Herceptin and that seems to be good enough for my med onc.
It seems that a very positive IHC indicates high overexpression and we go from there. But it would be interesting to know my FISH number - just to go with all the other numbers in my life!!
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