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I met a woman who's been on the Lapatinib trial since Nov. '04, and for whom it is working very well shrinking her brain mets. She even completed a half-marathon in May.
My sister participated in the trial for a couple of months this past winter, and unfortunately it did not work for her. She then had neurosurgery on her brain mets (NED in the rest of her body thanks to Herceptin), followed by stereotactic radiation, and is doing well now. Neither my sister or the woman we met had any noticeable side effects from Lapatinib.
Take heart and be hopeful -- Lapatinib seems to be working very well for a lot of women!
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