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Just a quick note: the European trial (and Canadian, Australian, etc.) that is testing herceptin for two years have been up and running since 2001, if I'm not mistaken. So, one good thing is that while they have no efficacy date yet, they have plenty of safety data (I have an email from Brian Leyland -Jones in Canada confirming this), and it's all good.
Email me off list (melnick@babson.edu) if you want a copy of a memo we wrote to Rachel's doc to try to get him to extend herceptin for a second year. He said no but I still think it was a good try!
Best,
Jeff
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