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Mike,
I haven't had lung mets, but have had local and regional recurrence(skin mets in mast. scar and over collarbone, and tumors in lymph nodes over collarbone and in neck and axilla). The first recurrence was treated successfully with Navelbine/Herceptin, as was the second recurrence which didn't include skin mets. Both regimens were weekly tx, for 6 months. I just finished up the second regimen. Navelbine is fairly tolerable for most, although blood counts will drop and she'll probably need injections to keep counts up. It's got a good track record for breast cancer mets, and was initially developed as a treatment for lung cancer. The difference in response between the local recurrence and the lung lesions is strange. It's good the local recurrence has remained stable, but obviously something has to be done about the lungs...If it were me, I would push for the most aggressive treatment for the lungs now, follow-up scans in a month to determine if there's any change; if not at least stable then biopsy. From what I know from other's experience here, the most aggressive tx would include one of the platin's...they can be very effective in combination with Herceptin. Please keep us posted, and take care.
Lolly
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