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Re: New Plan
I dont know what the MYK trial is but I know a little about Neratinib. It acts like Tykerb. It is used when the cancer cells become resistant to Tykerb. There is a single amino- acid change in the drug active site (I forgot what changes to what) and the Tykerb molecule cant hook imto the active site but Neratanib can. The dose of Neratinib is 240mg daily. Like Tykerb, Neratinib causes diarrhea and you have to watch heart function etc. Ill look up the two other drugs tomorrow. Hope this helps
Paul
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