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Re: Metformin, anything new?
Tiffany
Metformin is relatively safe. The one thing you have to watch is renal function. If a womans serum creatine reaches 1.4 there is a possible and serious problem with Lactic Acidosis. In the pharmacies we used to dispense a medicine called Phenformin or DBI-TD.
This drug was pulled off the market by the FDA around 1986 because of fatal cases of Lactic Acidosis. Metformin is a much safer Phenformin.
Interestingly Metformin can increase the mean life span of mice. This has nothing to do with cancer. Apparently stimulating that AMPK enzymes micis some of the biochemical effects of calorie reduction which long ago was shown to increase the life span of lab mice
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