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Old 06-09-2016, 02:16 PM   #1
Joan M
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Re: MM-302: HERMIONE study
SoCalGal, I think our posts crossed in cyberspace!! Glad to see that you're still on the board. We joined around the same time. Joan
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Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2023 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!
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Old 06-09-2016, 02:35 PM   #2
donocco
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Re: MM-302: HERMIONE study
Im delighted to be mistaken.Years of pharmacy practice have made me too cynical. I hope this MM-302 is a breakthrough

As far as Tofacitinib is concerned it is a Stat 3 inhibitor that is being investigated for various cancers. Ill have to do some research on both. When I had my own pharmacy way back when a pharmacist would call me and say "Guess what Paul they are coming out with a Zofran SR or whatever. Nothing more was said. It was understood that Zofran or whatever was going generic. In those days the generics were priced much lower than the brands. Now shamefully the price charged for the generics are skyrocketing.

Glad to be mistaken

Paul
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Old 06-10-2016, 01:25 AM   #3
michka
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Re: MM-302: HERMIONE study
Thank you Joan for sharing this information. I am always happy to see your posts and admire that you are so active at Asco! I hope you are well.
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08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex

12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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Old 06-10-2016, 12:08 PM   #4
Lani
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Re: MM-302: HERMIONE study
So Cal Gal--the chemo part of TDM-1 is a maytansinoid not an anthracycline.

Has a somewhat different mechanism of action. Sorry to be so picky, but I didn't want someone to say they failed on anthracyclines when asked if they failed on tdm1, as that might keep them from being offered some alternatives they might otherwise be eligible for.
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