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Old 04-28-2013, 11:47 AM   #1
AlaskaAngel
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Join Date: Sep 2005
Location: Alaska
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Question Re: New Drug for Vaginal Atrophy

What I don't quite understand about ospemifene is whether or not it is so different in some way from tamoxifen (which is also a SERM where the estrogen receptors bind to the drug) that it either does or doesn't offer the same benefit as tamoxifen (PLUS help with VVA).

Lani, can you help with this question?

A.A.
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Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
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Old 04-28-2013, 07:35 PM   #2
AlaskaAngel
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Join Date: Sep 2005
Location: Alaska
Posts: 2,018
Question New SERM for Vaginal Atrophy MAY be a tx for bc in the future

Testing of ospemiphene and 4-hydroxyospemifene in mice:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246110/
__________________
Dx 2002 age 51
bc for granny, aunt, cousin, sister, mother.
ER+/PR+/HER2+++, grade 3
IDC 1.9 cm, some DCIS, Stage 1, Grade 3
Lumpectomy, CAFx6 (no blood boosters), IMRT rads, 1 3/4 yr tamoxifen
Rads necrosis
BRCA 1 & 2 negative
Trials: Early detection OVCA; 2004 low-dose testosterone for bc survivors
Diet: Primarily vegetarian organic; metformin (no diabetes), vitamin D3
Exercise: 7 days a week, 1 hr/day
No trastuzumab, no taxane, no AI
NED
AlaskaAngel is offline   Reply With Quote
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