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Re: how long does it take for zeloda and tykerb to kick in
I have been on this combo now for just over 8 weeks. I started getting a rash last week. I saw almost immediate improvement (within first week and that was just on Xeloda) of my skin met. I had a scan this week and I have had a substantial reduction in most of my lung mets. My axilla node is gone as is my skin met (a little scarring but doesn't look active). I started on Xeloda - 8 tabs a day and tykerb 5 tabs a day - I have adjusted to 7 and 4. Now barely any gut issues at all, fatigue improved - just the mild skin reaction. This is the first combo I have had a decent response to so I am hoping it continues! Hope you are doing well.
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Amanda xx
40 year old Mum to three gorgeous kids - son 5 and daughters 8 and 11
Wife to my wonderfully supportive husband of 17 years!
22 February 2011 - Diagnosed Early Breast Cancer IDBC Stage2b (ER/PR -ve, Her2+ve +++) - 38 years old
(L) skin sparing mastectomy with tissue expander, axilla clearance (2/14 affected) clear margins.
Fec*3, Taxotere and herceptin*2 - stopped due to secondary diagnosis
June 24 2011 Stage IV - Skin met, axilla node, multiple lung lesions
Bolero3 trial - Navelbine, Hereptin weekly, daily Everolimus/Placebo
February 2012 - July 2012 Tykerb and Xeloda - skin mets resolved, Lungs initially dramatically reduced but growing again
August 2012 (turn 40!) tykerb and herceptin (denied compassionate use of TDM1) while holidaying in Italy!
September 2012 - January 2013 TDM1 as part of the Th3resa trial - lymph nodes resolved, lungs slowly progressing.
January 2013 - herceptin, carboplatin and Perjeta (compassionate access)
April 2013 - Some progression in lungs and lymph nodes - Abraxane, Herceptin and Perjeta
July 2013 - mixed response - dramatic reduction of most lung disease, progression of smaller lung nodules and cervical and hilar nodes - ? Add avastin.
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Hybrid Mode
