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Old 11-17-2011, 06:06 PM   #1
Laurel
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Re: brain changes associated w chemo induced cognitive dysfunction identified

Lani,

I am glad you are raising the question of anti-hormonal therapy and cognitive function. I had long considered my "fluffiness between my ears" to be exacerbated by the A.I. I am taking. I suspect when someone subdivides the anti-hormonal patients from the other post-chemo patients they will find the cumulative effects of chemo and anti-hormonals to be considerably more affecting.
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Dx'd w/multifocal DCIS/IDS 3/08
7mm invasive component
Partial mast. 5/08
Stage 1b, ER 80%, PR 90%, HER-2 6.9 on FISH
0/5 nodes
4 AC, 4 TH finished 9/08
Herceptin every 3 weeks. Finished 7/09
Tamoxifen 10/08. Switched to Femara 8/09
Bilat SPM w/reconstruction 10/08
Clinical Trial w/Clondronate 12/08
Stopped Clondronate--too hard on my gizzard!
Switched back to Tamoxifen due to tendon pain from Femara

15 Years NED
I think I just might hang around awhile....

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Old 11-18-2011, 03:19 PM   #2
MJo
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Re: brain changes associated w chemo induced cognitive dysfunction identified

When I met my onc in 2006 and told him I was a business writer, he told me that chemo might affect my work. I am different now. I can't write or think as fast. I'm not as "imaginative." When I tell myself it could be age related, I remind myself that Hillary Clinton is secretary of state! Yeah, it's better than being dead. These side effects aren't terrible, but they are noticeable. So oncologists suspected long-term side effects back in 2006.
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IDC, Stage I, Grade 2
Oncotype DX Score 32
Her2++ E+P+, Node Neg.
Lumpectomy 11/04/05 Clear Margins
3 Dose dense AC (Couldn't tolerate 4)
4 Dose dense Taxol & Herc. (Tolerated well)
36 weeks Herceptin (Could not complete one year due to decrease in MUGA score)
2 years of Arimidex, then three years of Femara
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