Expert Review of Anticancer Therapy
August 2011, Vol. 11, No. 8, Pages 1151-1153 , DOI 10.1586/era.11.106
(doi:10.1586/era.11.106)
Omega-3 fatty acids: a potential booster for tamoxifen therapy?
Lucas Tadeu Bidinotto, Ricardo López de Cicco & Jose Russoâ€*
http://www.expert-reviews.com/doi/fu...586/era.11.106
Quote from paper
"In summary, there are several pathways by which omega-3 fatty acids can act in an anticancer response. The downregulation of the CDK1-cyclin B1 complex, resulting in prolongation of the G2-phase, and the downregulation of the MAPK pathway may be responsible for slowed breast cancer growth. Increased lipid peroxidation along with the accumulation of ROS and downregulation of Akt may be responsible for an increased apoptotic index. The improvement of the immune response against tumors and the lack of inflammatory cytokines in the tumors of animals fed omega-3-rich diets and treated with tamoxifen contribute to the impairment of tumor growth. The improvement of wasting syndrome in patients with advanced cancer may contribute to their overall health. Finally, the increased membrane fluidity may improve the internalization of chemotherapeutic drugs. Therefore, the combination of these mechanisms represents a potential boost to tamoxifen therapy."
Hybrid Mode
