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Old 01-24-2011, 07:54 AM   #1
Joan M
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Re: drugs already approved indirectly attack breast cancer stem cells (responsible fo

Perhaps Rituxan (rituximab) is one such drug. This drug is used for certain types of non-Hodgkin's lymphoma, but also I believe for rheumatoid arthritis and is also an anti-inflammatory. I understand that cancer involves inflammation of a sort.

And Rich, you're right. Shoddy reporting.

Joan
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Diagnosed stage 2b in July 2003 (2.3 cm, HER2+, ER-/PR-, 7+ nodes). Treated with mastectomy (with immediate DIEP flap reconstruction), AC + T/Herceptin (off label). Cancer advanced to lung in Jan. 2007 (1 cm nodule). Started Herceptin every 3 weeks. Lung wedge resection April 2007. Cancer recurred in lung April 2008. RFA of lung in August 2008. 2nd annual brain MRI in Oct. 2008 discovered 2.6 cm cystic tumor in left frontal lobe. Craniotomy Oct. 2008 (ER-/PR-/HER2-) followed by targeted radiation (IMRT). Coughing up blood Feb. 2009. Thoractomy July 2009 to cut out fungal ball of common soil fungus (aspergillus) that grew in the RFA cavity (most likely inhaled while gardening). No cancer, only fungus. Removal of tiny melanoma from upper left arm, plus sentinel lymph node biopsy in Feb. 2016. Guardant Health liquid biopsy in Feb. 2016 showed mutations in 4 subtypes of TP53. Repeat of Guardant Health biopsy in Jana. 2021 showed 3 TP53 mutations, BRCA1 mutation and CHEK2 mutation. Invitae genetic testing showed negative for all of these. Living with MBC since 2007. Stopped Herceptin Hylecta (injection) treatment in March 2020. Recent 2023 annual CT of chest, abdomen and pelvis and annual brain MRI showed NED. Praying for NED forever!!

Last edited by Joan M; 01-24-2011 at 07:56 AM..
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Old 02-04-2011, 08:54 PM   #2
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Re: drugs already approved indirectly attack breast cancer stem cells (responsible fo

http://www.cancer.med.umich.edu/news...atment10.shtml

Repertaxin blocks interleukin 8 and interrupts a critical signal that allows breast cancers cells to grow. This may not be one of the drugs mentioned in the article you folks are discussing. But perhaps still useful information, so I wanted to make it available to you.

I'm not a cancer patient or a cancer survivor. I do in depth research related to investing in biotech and have a science background. I just happened onto your website while investigating the relationship between cancer stem cells and pro-inflammatory cell signalling.

Another already approved drug worth looking at is itraconazole. It's an anti-fungal that has been found to block the SHH pathway, which appears to play a role in cancer stem cell growth.

http://www.reyalab.org/manage/user_f...1274278169.pdf

Best to all.
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