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Re: The weakly er+ group
Alice
At SABCS 2007 there was a presentation aimed primarily at ER+PR- tumors where they took a "molecular" picture of the tumors and compared them to the molecular pictures of ER+PR+ and ER-PR- tumors.
Bottom line is some ER+PR- tumors look like ER+PR+ tumors and some look like ER-PR- tumors and some are truly unique and are thus ER+PR- (but just a small portion).
However, the presenter also said that some ER+PR+ tumors look like ER-PR- tumors (and vice versa) and this is probably what happened to you (perhaps).
They did not do this in conjunction with any other markers (such as Her2) but the presenter was indicating that this may be why some women don't respond to endocrine therapies - because their hormone positive cancer is actually very different than what is expected.
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Kind regards
Becky
Found lump via BSE
Diagnosed 8/04 at age 45
1.9cm tumor, ER+PR-, Her2 3+(rt side)
2 micromets to sentinel node
Stage 2A
left 3mm DCIS - low grade ER+PR+Her2 neg
lumpectomies 9/7/04
4DD AC followed by 4 DD taxol
Used Leukine instead of Neulasta
35 rads on right side only
4/05 started Tamoxifen
Started Herceptin 4 months after last Taxol due to
trial results and 2005 ASCO meeting & recommendations
Oophorectomy 8/05
Started Arimidex 9/05
Finished Herceptin (16 months) 9/06
Arimidex Only
Prolia every 6 months for osteopenia
NED 18 years!
Said Christopher Robin to Pooh: "You must remember this: You're braver than you believe and stronger than you seem and smarter than you think"
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