1000% increase in chemotherapy efficiency with prozac!

[Rich66]

Suggesting Prozac has anticancer properties by itself:


1: Cancer Biol Ther. 2008 Oct;7(10):1685-93. Epub 2008 Oct 22. Links
Fluoxetine inhibits the extracellular signal regulated kinase pathway and suppresses growth of cancer cells.

Stepulak A, Rzeski W, Sifringer M, Brocke K, Gratopp A, Kupisz K, Turski L, Ikonomidou C.
Department of Pediatric Neurology, Children's Hospital, Medical Faculty Carl Gustav Carus, University of Technology Dresden, Dresden, Germany. andrzej.stepulak@uniklinikum-dresden.de
Fluoxetine (FLX) is a widely prescribed antidepressant. Concerns were raised about the potential impact of FLX on cancer growth, because FLX was shown to promote development of breast cancer in rodents. Here we studied the effect of FLX on tumor growth in lung (A549), colon (HT29), neuroblastoma (SKNAS), medulloblastoma/rhabdomyosarcoma (TE671), astrocytoma (MOGGCCM) and breast (T47D) cancer cells and explored potential mechanisms of its action. In our study, FLX reduced growth of cancer cells in vitro in a concentration dependent manner. The antiproliferative effect of FLX was already evident after 24 hours exposure and more pronounced at 96 hours. We demonstrate that FLX inhibits phosphorylation of ERK1/2 kinases in a time and concentration-dependent manner, followed by reduced phosphorylation of transcription factor c-Myc in A549 and HT29 cells. After treatment with FLX, A549 and HT29 cells demonstrated concentration-dependent decrease in the expression of c-fos, c-jun, cyclin A, cyclin D1, and increased expression of p21(waf1) and p53 genes, which resulted in slowing of the cell cycle progression. We suggest that these changes could be responsible for observed inhibition of cancer cell proliferation during FLX treatment in vitro.
PMID: 18836303 [PubMed - indexed for MEDLINE]

[Brenda_D]

Interesting. I was put on prozac after chemo, as a SSRI
inhibitor to help me sleep. I wonder if it made a difference with the Adryamicin I took just weeks before?

[fullofbeans]

Thank for the extra search Rich, Yes why do we not hear more about it? well I have my own theories, just like why do we not hear more about Yamanoto's experiments..

Anyhow it would have to be taken at the same time than chemo (chemo is only active for few hours and the rest of the time your body is dealing with the side effects). Some patient are on prozac when receiving cancer treatments so we already know that it should be safe. I am not advising on anything I am just informing.