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Mk-0752
is a gamma secretase inhibitor which interferes with the notch pathway, which is felt to be essential for cancer stem cells.
Dr. Max Wicha has been talking about using gamma secretase inhibitors as cancer stem cell specific drugs for years--this particular one has been studied quite a while as it has been under development against Alzheimer's
Rich sounds like you have now discovered the cancer stem cell literature. I urge you to read Dr. Wicha's publications and listen/look at his talks at AACR, ASCO, etc (many are online). He GETS it. I was present for that Barsky talk at the AACR in 2008--it was a precedent-setting talk, but got no coverage and most oncologists and cancer researchers never heard its results.
I recently spoke with a friend whose husband had two stem cell transplants for lymphoma (lasting 12+ years) who suddenly died of lung cancer (donor was same sex, but they were looking into other genetic tell-tale signs of
the lung cancer being "donated" along with the stem cells.
Dr. Wicha thinks radiation therapy may make things worse rather than better.
I encourage you to seek out his contributions.
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