More evidence Omega 6 LA is implicated in BC.
And why COX blockers may have an impact as the block these pathways.
And more PGE2
may = more aromatase = more oestrogen products
More oestrogen would result in more conversion of LA to AA the raw material for this process be enhancing long chain fat conversion.
SO this could be a self fuelling tumour loop where Omega 6 is present in excess and there is no Omega 3 to moderate the process.
RB
http://www.springerlink.com/content/n547j2538p317388/
Xin-Hua Liu1, Jeanne M. Connolly1 and David P. Rose1 Contact Information
(1) Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, New York, USA
(2) Division of Nutrition and Endocrinology, American Health Foundation, 10595 Valhalla, NY, USA
Received: 21 August 1995 Accepted: 27 October 1995
Diets rich in linoleic acid (LA) stimulate the metastasis of MDA-MB-435 human breast cancer cells from the mammary fat pads of nude mice.
This omega-6 fatty acid is metabolized to various cyclo-oxygenase and lipoxygenase products, several of which have been previously associated with tumor cell invasion and metastasis. We now report that MDA-MB-435 cells secreted increased levels of prostaglandin E2 (PGE2),
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