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Hi Irene! If it's any help, Nicola was on a clinical trial/study of Lapatinib(Tykerb) and Herceptin. She was also on Taxol at the same time, though. Everything worked great for about a year and 3 months, then there was a progression, so they pulled the Lapatinib and Taxol and switched to Navelbine, I think. The Tykerb crosses the BBB and she took 4 pills in the morning. She had the usual diadammitrhea, and during the trial they kept trying to blame it on the Taxol, but she knew it was the Tykerb. I'm not an expert, Irene, but I think its a good combo. You are attacking the cancer cells from the inside and out at the same time, I seem to recall. Thoughts and prayers, Love, Bill
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