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03-23-2008, 11:40 AM
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#1
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Senior Member
Join Date: May 2007
Location: DFW area (TX)
Posts: 431
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Becky, have no idea of that one, but it sure is interesting if so. I was theorizing that working ovaries "sense" the lowering of estrogen in the body from the AI's and thus work harder to make more.
TO all following this conversation; do you have any opinions on DIM supplements? I didn't realize these may work specifically on the estrogen factor until reading a bit more lately.
TRS
__________________
Terri, spouse of Ruth, Dallas/Ft. Worth area
Ruth dx 05/01/07 (age 50) Filipino
multifocal, several tumors .5 -2.5 cm, large area
Breast MRI showed 2 enlarged nodes, not palpable
100%ER+, 95%PR+, HER2+++
6x pre-surgery TCH chemo finished 9/15/7 Dramatic tumor shrinkage
1 year Herceptin till 6/08
MRM 10/11/07, SNB: 0/4 nodes + Path: tumors reduced to only a few "scattered cells"
now 50% ER+, PR- ???
Rads finished 1/16/08
Added Tamoxifen,
Finished Herceptin 05/08
NOW is the time to appreciate life to the fullest.
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03-28-2008, 12:25 AM
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#2
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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Beckys post
Becky,
If the lack of estrogen is what is causing the symptoms of joint pain, I wonder why it is that some some AIs such as Aromasin or Femera cause some women less joint pain then Arimadex?
maryanne
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*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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03-28-2008, 08:05 AM
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#3
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Senior Member
Join Date: Jan 2007
Location: Media (Wawa to be exact), PA
Posts: 104
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I just recently started taking Aromastin. For those of you that have been on ANY these AI's how long did it take before you became aware of the side effects such as trigger finger and joint pain. Any other side effects noticed?
__________________
DX BC 12/06
tumor .9
Lumpectomy 1/8
Mammosite radiation completed 2/10
Stage1/Grade 1
clear Margins /Nodes Neg
ER+
IHC +2 Fish +
ONCO 23
Started TCH on 3/2 for 6 rounds of TC once every three weels and a year of Herceptin every 3 weeks -
Finished everything and now on Aromasin
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03-28-2008, 09:41 AM
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#4
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Senior Member
Join Date: Jul 2006
Location: Shingle Springs, CA - near Sacramento
Posts: 295
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Thank you, again!
Dear Becky,
Thanks so much for once again for your time and trouble to answer my question in terms I can understand. Your responses are always clear and illuminating. Your participation on this board is invaluable and I just want to say THANK YOU! HAVE A GREAT DAY!
Donna
P.S. just a "I wonder if" thought, would overweight women have a greater propensity to this tendon anomaly? I am overweight and I wonder just how hard those poor AI's have to work.....:-)
__________________
Donna in the Sierra Foothills of California
Diagnosed 6/7/06 invasive ductal carcinoma/ductal carcinoma in situ
Lumpectomy 6/21/06
Pathology: Er 99% Pr 10% Her2/neu 3+
DNA Index 1.0
S-Phase 3/High
Primary Tumor 2.4 cm Sentinel Node Tumor 2.1cm
A/C/T+ Herceptin + rads + Arimidex
stopped Herceptin after 7 mos. due to low MUGA
Surgery for thickened uterine tissue May 2008 - conclusion: side effect of Arimidex
Switched from Arimidex to Femara - joint/tendon problems significantly better!
2 year mark Pet scan and Echo shows all clear!
5 year mammogram with ultrasound shows no sign of cancer - yay!
11 years, 11 months new breast cancer - found lump
Mastectomy 4/30/2018
Pathology: Er99%, PR 28%, Her2 negative! (new type)
Faslodex
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03-28-2008, 10:28 AM
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#5
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Senior Member
Join Date: Dec 2006
Location: WHITESTOWN IN
Posts: 148
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I was only on tamoxafine for about 3 months when they switched me to femara after my hysterectomy. I had no side affects for the first 2 months but for the last three have had horrible joint and bone pain, not to mention the swelling in my hands. Some days I have no feelinging in either hand or only partial fingers. My knees hurt the most and with my physical job I'm in trouble. My Onc wants me to stay on it for at least 9 months to see if it lessens and then he might switch me. He believes there is no validity to switch. So we will wait it out a little longer.
__________________
DX IDC AT 42 12/7/06
2.2CM STAGE I GRADE 2
NODE NEG
PARTIAL 12/18/06
HER2+ /ER+(75%) PR+(5%)
4 DD AC CHEMO STARTING 1/10/07
4 DD Taxol Starting 3/5/07
1year weekly Herceptin starting 3/5/07
finished 2/18/08
changed to every 3 weeks 4/23/07
completed 33 radiation treatments 7/6/07
TAH and BSO 9/24/07
start Femarra 10/8/07
Started Neritinib trial 12/14/09
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03-28-2008, 10:51 AM
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#6
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Senior Member
Join Date: Mar 2007
Location: Hilo, Hawaii
Posts: 1,867
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It took me a few months to feel any joint side effects. I woke up in th middle of the night one night and my thumb was locked and I had to manually unlock it. I thought....."wow, that was REALLY wierd"....I had no idea it was from the Arimadex. During the day it was like nothing happened, then at night when I woke up, sure enough same thing.
harriecanarie
__________________
*** MARYANNE *** aka HARRIECANARIE
1993: right side DCIS, lumpectomy, rads
1999: left side DCIS, lumpectomy, rads, tamoxifen
2006:
BRCA 2 positive
Stage I, invasive DCIS (6mm x 5mm)
Grade: intermediate
sentinal node biopsy: neg
HER2/neu amplified 4.7
ER+/PR+
TOPO II neg
Oncotype dx 20
Bilat mastectomy with DIEP flap reconstruction
oophorectomy
2007:
6 cycles TCH (taxotere, carboplatin, herceptin)
finished 1 yr herceptin 05/07
Arimidex, stopped after almost 1 yr
Femara
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