Olive oil and Her2 downregulation - question for the propellerheads

[chrisy]

On the other hand... these articles suggeststhat something in EVOO reverses herceptin resistance by reducing the cleavage of the Her2 extracellular domain which as I read it, would present more receptors for the herceptin to bind to.

We are certainly complicated creations, aren't we?? I definitely need some expert help in interpreting this stuff.

Maybe I can get Dr. Menendez to accompany me to my appointment. Of course, I think he's in Spain now, so that might be a problem.

http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

[RobinP]

Chrisy, you did introduce a very interesting and good question, which is very technical and difficult to answer. I just want to further clarify this topic... doesn't olive oil reduce the number of her2 docking sites where herceptin would bind, not increase it? Because according to one of the articles you posted above, " oleuropein aglycone ( olive oil) treatment significantly reduced (note not increase!) HER2 ECD cleavage OR HERCEPTIN DOCKING SITES and subsequent HER2 auto-phosphorylation. " Wow, I am certainly not an expert, but Iam trying to help.I surely hope you can reach the researchers and clarify some of your pertinent questions and whether taking olive oil will effect your trail. I wish you the very best of luck and hope the new trail Herceptin you are trying will be very effective and completely successful! You deserve the very best. Take care. Please continue to post and let us know how you are doing in your trail. Praying for you.