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Old 01-03-2008, 07:10 AM   #1
Cathya
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Join Date: Sep 2005
Location: Ontario, Canada
Posts: 752
Lani;

Exactly what test should one have done to get a total genetic picture of their tumor? Living in Canada it is not easy to get genetic testing done (and very expensive) so while I am interested I would like to be sure I am asking for the right test.

Thanks,

Cathy
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Cathy

Diagnosed Oct. 2004 3 cm ductal, lumpectomy Nov. 2004
Diagnosed Jan. 2005 tumor in supraclavicular node
Stage 3c, Grade 3, ER/PR+, Her2++
4 AC, 4 Taxol, Radiation, Arimidex, Actonel
Herceptin for 9 months until Muga dropped and heart enlarged
Restarting herceptin weekly after 4 months off
Stopped herceptin after four weekly treatments....score dropped to 41
Finished 6 years Arimidex
May 2015 diagnosed with ovarian cancer
Stage 1C
started 6 treatments of carboplatin/taxol
Genetic testing show BRCA1 VUS
Nice! My hair came back really curly. Hope it lasts lol. Well it didn't but I liked it so I'm now a perm lady
29 March 2018 Lung biopsy following chest CT showing tumours in pleura of left lung, waiting for results to the question bc or ovarian
April 20, 2018 BC mets confirmed, ER/PR+ now Her2-
Questions about the possibility of ovarian spread and mets to bones so will be tested and monitored for these.
To begin new drug Palbociclib (Ibrance) along with Letrozole May, 2018.
Genetic testing of ovarian tumour and this new lung met will take months.
To see geneticist to be retested for BRCA this week....still BRCA VUS
CA125 has declined from 359 to 12 as of Aug.23/18


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Old 01-03-2008, 11:50 AM   #2
Lani
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the test as of now is not commercially available

a variation of it, the 70 gene Mammaprint, developed by a team in the Netherlands, is, but I am not sure if they will provide you with the actual info from the 1000s of genes studied on the microgene array and it can only be run on fresh frozen tissue taken at the time of surgery. A team at MD Anderson is also trying to offer a test which will document the relevant genes in all types of breast cancer for treatment decisions, but it is not yet commercially available.

I try to post interesting, helpful and/or hopeful items that I hear at meetings and that I read--some things are immediately available (eg Boswellia serrata) others are cutting edge findings from research many of which are not yet available and certainly are not "standard of care" everywhere.

Unfortunately when we talk about personalized treatment of cancer, we are not there yet. But we might speed things up if we keep informed and push our government to fund cancer research.
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Old 01-04-2008, 05:32 PM   #3
eric
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Join Date: Sep 2005
Posts: 589
Sorry but I don't see Hot 5. Any other direction?
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