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12-19-2007, 11:35 AM
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#1
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Irene,
I'm so sorry to hear that you have progression. I can't offer you any advise regarding which chemo cocktail might work but want you to know that you are in my prayers. You have been through so much and I know that you will do your research and between you and your oncologist will come up with a combo that will knock the mets out of the ball park.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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12-19-2007, 03:04 PM
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#2
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Senior Member
Join Date: Nov 2005
Location: Lincoln, Rhode Island
Posts: 371
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Hi Irene,
I was thinking of the new drug Ixempra also. As you I have also used a lot of treatments. Just Know I am praying that you find the right treatment and kick butt!
__________________
Love and Hope
Karen
IDC
DX 1998 STAGE I ER+/ PR+
AC CHEMO TILL FEB 1999
Tamxofin till 2001
2001 exstensive liver mets and mets to lungs
Started weekly taxol
Jan 2002 found out I was strongly HER2POS+++ started herceptin continued with taxol and herceptin till June 2002 then from June 2002 till Jan 2005 just herceptin and Arimidex
2005 Navelbine herceptin had RFA Then back on taxol with herceptin
April 2006 progression again went on clinical trial with tykrerb/herceptin progressed on the started Xeloda/ herceptin
Feb 2007 started Doxil
August 2007 Taxotere,Carboplatin and Herceptin exstensive mets to liver and pancreas
October 2007 Had to stop Carboplatin due to sever allergic reaction
Jan 2008
Stopped Taxotere due to progression now on Gemzar and Herceptin
March 2008 Starting Carboplatin, Abraxane, and Herceptin.
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12-20-2007, 06:38 PM
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#3
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Senior Member
Join Date: Sep 2005
Location: Newton, MA
Posts: 951
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Herceptin MCC DM1 trial
Hi Irene,
I saw my oncologist who is treating me for this trial. I told him about you and he said that you would not be limited by the treatment you have had to qualify for the trial I am on. I am on a weekly phase 1 trial of this drug that is testing a higher dose. The trial that Lily is on is given every three weeks, is phase two, and has different criteria. It is an offshoot of the the previous stage 1 trial. I would suggest investigating this drug. All of the patients at Dana Farber are doing well on it. My oncologist presented at San Antonio.
I am doing well. My scans look great and my bone scan indicated that the bones are healing. Both of my tumor markers are now normal. CEA is now 1.7.
Best wishes,
Barbara H.
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12-20-2007, 09:16 PM
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#4
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Senior Member
Join Date: Aug 2001
Location: Oregon
Posts: 1,756
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Barbara, are there other sites doing the Phase I that you're on? Closer to the west coast would be so cool! It's really exciting that you're doing well, CEA normal, bones healing. Wow. I'm hoping to be able to get on it, if not in trial then asap.
<3 Lolly
__________________
Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.
Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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12-24-2007, 02:03 PM
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#5
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Senior Member
Join Date: Sep 2005
Location: Central Coast, CA
Posts: 3,207
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Irene,
I've been thinking of you a lot, and how you are again searching for new solutions. Sounds like the Herceptin DM1 might be a possibility, and you certainly have access to the best doctors (including yours who seems endlessly creative and really works hard on your behalf). I heard a discussion in San Antonio on the H-DM1 in which the researcher was saying this agent was great against cancer but in the past it had been TOO TOXIC to use. Now attaching it to the Herceptin (like a guided missile) they could finally use it to benefit patients
I remember your post OVER a year and a half ago which I think was titled "running out of options". Followed by your pioneering with tykerb/xeloda which gave you a longer run than you'd seen in many years.
Here's hoping that you will find an even better weapon this time around.
Much love and many blessings to you, my friend.
Chris
__________________
Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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12-24-2007, 03:47 PM
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#6
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Senior Member
Join Date: Sep 2006
Location: Houston, Texas
Posts: 624
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I can't give you any better advice than anyone else has, but just know I am thinking of you and praying for you. It sounds like you are in good hands. Keep up the battle!
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01-24-2008, 09:50 PM
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#7
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Senior Member
Join Date: Dec 2006
Location: Oregon
Posts: 715
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Thinking of you
Irene,
All the best to you with this new progression. So delighted that there are so many good minds on this site. Glad you have a good mind and a good doctor. I am here as part of the support team.
Hugs from me, Catherine
__________________
Catherine
Found my own lump in the shower
April 2006 at the age of 58
Stage IIB, ER- PR- HER2+++ multi focal tumors, largest 2.3cm
Chemo first: AC/Taxol over 16 weeks
Bilateral mastectomy Sep 06
33 rads after the surgery
1 year of Herceptin completed Dec 07
15 years and no recurrence as of April 2021
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