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Old 10-07-2007, 05:59 AM   #1
lilyecuadorian
Senior Member
 
Join Date: Mar 2007
Location: CHARLOTTE NC USA Home town (ECUADOR) South America
Posts: 542
I wish to have the answer Mary Anne in TX ..before I go again and can ask the research oncology that is doing the research on this trial that I'm waiting to get ready I hope so is the same investigational drog !!!
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Lily
Diag April/06 5 months after give birth my son Max
stage IV mets on liver (5 tumors) 38 year old,
her2+++ and ER+PR+ from32 nodes 4 positives
mastectomy right breast chemo before surgery herceptin/carboplatin/taxotere ,clear and surgery have radiation 20, `& then herceptin and tamoxifen
NED until Aug/07 body only then 'n June 04-06-07 .1 lesion of 1.6 cm on cerebellum ...novalis ,open sugery
5m.m brain met again novalis, 4mm.In the liver. Waiting 2 months now 3 tumors enroll on T-MCC trial start first infusion Nov 5/07 at Dec 17 scan show one tumor despair the 2nd and 3th diminish Doc said great results until March/08 ct scan show progression
03-05-08 start tykerb & xeloda
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Old 10-08-2007, 09:51 AM   #2
Lani
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Join Date: Mar 2006
Posts: 4,783
Mary Anne

As I understand it, the DM1 drug is even larger than herceptin because it is a herceptin antibody linked to a chemotherapy drug. It is not a pro-drug as I understand it (one in which the two parts of the combination are separated before the drug works, for example by processing in the liver)

So if you are looking for a "smaller herceptin" perhaps that is what you or someone else called a receptor tyrosine kinase inhibitor (like Tykerb) or an interfering RNA (none have yet been developed into drugs and unfortunately it looks like a while before they do) or perhaps something else altogether. Please let me know when you find the link you are referring to--maybe it is something I have missed altogether(very possible despite the volume of my reading)
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