Tykerb rash

Joy · 08-25-2007, 08:21 AM

I'm glad you shared cause I'm having similar stuff. And have been on it for about 10 weeks. I just try to think that it is still being aggressive, but today and yesterday the itcing is driving me a little crazy and I have had success with aveeno hydrocortisone cream. Of course the scalp thing is still a problem. Sometimes I feel like a monkey.

Daisypink · 08-27-2007, 01:05 PM

Hi

I am so glad i spotted this thread as i was going post about this.. i'm on the LEAP trial over here in England (very lucky to get it), Xeloda/Tykerb 2 weeks on 1 week off - tykerb continiuosly.. i've just completed cycle 3.. i'm on 3300mg of xeloda and 1250mg tykerb.

It seems i also have the Tykerb rash over the weekend.. it started off on my neck like a heat rash and it was itchy, now its dried up and it looks like eczema. I have little patches of it on my face and also on my scalp.. thats very sore.

I phoned my hospital and my oncologist has susggested i try putting the udderly smooth cream i have on it and take some piriton.. hope i'm doing right.. does anyone know if they reduce the dose because of this.. i hope not..

I just read that if you get the rash its a good sign that its working for you.. is this right?? how do we know this??

does anyone know??

Lots of love jakki
x

awjkej · 09-19-2007, 08:09 PM

Hi Jakki,

I experienced very similar side effects as you. The rash on my face was so bad and painful, that I went down to 1000mg from 1250mg and that worked. My arms and feet began to be very painful and sore, tender so I am now down to 750mg. I have to day though that the difference between the 1000 mg and the 750 mg is neglible, whereas the dropping to 1000mg made a huge difference.

I do the 3 week on 1 week off and 3300mg of xeloda.

My onc told me that tykerb is metabolized differently by each woman and that a liver enzyme cytochrome p450 is involved with the process. He said that some women are on 250 mg up to 1500mg depending on what they can tolerate. So it is my understanding that it isn't a one size fits all dosage for tykerb.

Hope this helps.
Anne