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I have been wondering about this as well. Herceptin was very good to me for 3 1/2 years, and there are currently trials being conducted to see if the combination of Herceptin/Tykerb have synergistic effects together.
There is no concrete data on it, but I'm thinking of asking my onc about putting me back on Herceptin as well.
If there was toxicity, we should be able to stop the Herceptin, I would think? I was initially on Herceptin/Tykerb/Xeloda for the first 6 weeks that I was on Tykerb, and did not notice any increased side effects. My onc took me off Herceptin, for the same cautious reasons other onc's have given. My CA 27-29 plunged 300 points in the first 3 weeks I was on that combination.
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