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07-14-2007, 07:53 AM
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#1
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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I know you will fight this mommy! we'll kick this to the curb! love you...
jennifer
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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07-14-2007, 08:21 AM
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#2
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Senior Member
Join Date: Jul 2005
Location: Ft. Collins, Colorado
Posts: 546
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I second the damn't! I was really surprised to see this post, Kate and I'm just so sad and frustrated for you. Ugh, this stupid disease! HOWEVER you have gotten great advice here and yes we are here and you CAN depend on us. I will be anxious to hear what your onc recommends and remember this will be a 'first-line metastatic treatment' that is good as the right combo can really kick thos stupid spots. Search the forums for lung mets and treatments and if you are up for it-you are a great researcher, but if you want others to do it, just ask-google first line treatments for bc lung mets and see what happens, or look at some late phase trials, but there are good treatments for this.
I'm looking forward to hearing what you decide and how you are doing and I'm sending you great success vibes!
Love to you and yours!
__________________
with love and gratitude,
joy
dx stage I 2/2000*er/pr+; her- per IHC*lumpectomy*4 rounds A/C*30 rads*tamoxifen*dx stage 4 5/2002*huge mets to liver*tiny mets to lungs*stopped tamoxifen*5/02 taxotere/xeloda*her 2 checked with FiSH-her2+++herceptin *2/03 stopped chemo femara w/herceptin*zolodex*04 switched to aromasin w/herceptin*05 high estrogen tx*11/05taxol/carbo*7/06 stopped chemo; megace/herceptin*9/06navelbine/herceptin*5/07tykerb/xeloda great response*4/08 progression in liver; ooph/ faslodex /herceptin
6/08 began Herceptin DM-1
9/08 progression
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07-14-2007, 09:31 AM
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#3
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Senior Member
Join Date: May 2006
Location: northshore suburb of chicago
Posts: 1,093
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Oh Kate, I just hated hearing your latest news. This disease is definitely unpredictable at any given time. Darn it. Keep up your positive spirit and continue to fight this with every ounce of strength you have. I wish you success in finding the right treatment and in fighting these lung mets. You and your onc were so on top of things and so wise to get that ct scan. Good lesson for all of us to make sure we keep our oncs and ourselves on our toes.
__________________
~Rina~
Dx:3/06 had a lumpectomy April 19, 2006
Her2+ er/pr- Stage I Grade 3 tumor size 1.4 cm, node negative
AC 4 dense doses
34 radiation treatments including booster doses
receiving herceptin every 3 weeks since late August 2006 for 12 months
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07-14-2007, 09:49 AM
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#4
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Senior Member
Join Date: Jan 2007
Posts: 138
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Kate,
I am sending you and your family strength, hugs and prayers. I know you will beat this.
Stay strong.
Karen
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07-14-2007, 10:19 AM
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#5
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Senior Member
Join Date: Sep 2006
Location: Savannah, Georgia
Posts: 301
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Kate,
I am so sorry that you are having to deal with this. I do feel the same way that you do- you've caught them early and you have many many options. You are a very strong person and I have no doubt that you will knock this down and be back to NED in no time. You are in my thoughts and prayers.
Love, Kelly
__________________
dx'd 05/06, 37 years old
er/pr-, Her2+, grade 3
double mastectomy, immediate reconstruction- implants
Stage 2b, 2 tumors- 2.2 cm and 0.6 cm, 3/5 + nodes
all scans clear
genetic testing- negative
06/06 began dd A/C x 4, 12 weekly Taxols w/ Herceptin
30 rads
Herceptin weekly x 1 year
Herceptin completed 08/07
Port removed 12/26/07 MERRY CHRISTMAS!!!!!!
05/17/08 Two year anniversary NED
"We gain strength, courage, and confidence by each experience in which we really stop to look fear in the face... you must do the thing that you think you cannot do."
-Eleanor Roosevelt
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07-14-2007, 10:47 AM
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#6
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Usefullness of HER2 serum test
Just thought I'd let everyone know that my baseline HER2 serum test was 10.1. So, when it went up to 9.5 something in my head told me something was wrong even though it was still within "normal"
I now am a firm believer in the usefullness of the HER2 serum test to monitor progression.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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07-14-2007, 11:27 AM
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#7
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Senior Member
Join Date: Feb 2005
Location: Wisconsin
Posts: 159
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hi Kate--
I'm really sorry to hear about this. Your situation isn't that different than mine was. PLEASE keep us posted.
I have a question--one of the things that I've never looked into is the serum tests--I don't have a baseline. Can you or anyone else tell me exactly what test your docs are running? Is the Bayer serum test that Walt Carney worked on? I really should check into that.
Hang in there, Kate...my thoughts are definitely with you :-)
Val
__________________
BLOG:
http://valleygirlvnp.blogspot.com/
Dx 11/04, Age 42, ER-/PR-, HER2+++
3 months weekly Herceptin, Taxol. Carboplatin
Significant tumor shrinkage
Mastectomy 3/05; Stage 3b, 9 cm tumor, 5/8+ nodes
3 more months weekly Herceptin, Taxol. Carboplatin
7/05 30 radiation treatments, IMRT planning approach
Started 1 year of Herceptin 9/05
9/06 Began quarterly triple doses Herceptin. Brain & breast MRIs semi annually.
* * * * * * * * * * * * * * * * * * * * * * * * * * *
6/08 Right breast, intraductal carcinoma, high nuclear grade associated with comedo necrosis; extensive diffusely involved the entire biopy specimen. ER+, PR-, Her2 unknown at this point, 07/08 mastectomy.
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07-14-2007, 04:13 PM
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#8
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Senior Member
Join Date: Nov 2005
Location: Ireland
Posts: 3,463
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Kate can I ask you, if you had'nt had the her2 serum test would you have known to ask for other tests? Did you have other symptoms? I only ask because I live in Ireland and my onc does'nt do her2 serum tests. I'm also a smoker and obviously worry about lung mets.
__________________
Tricia
Dx July '05 IDC 1.9cm Triple positive 3/9 nodes positive
A/C X 4 ..Taxol/Herceptin x 12 wks then herceptin 1 yr
Rads x 36 ..oophorectomy August '06
Currently taking Arimidex..
June 2011 osteopenia/ zometa x1 yearly- stopped Zometa 2015 as Dexa show normal bone density.
Stopped Arimidex July 2014- Restarted Arimidex 2015 for a further two years on the advice of my Onc.
2014 Normal Dexa scan
2018 Mammo all clear, still NED!
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07-14-2007, 02:11 PM
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#9
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Senior Member
Join Date: Sep 2006
Location: Marengo, IL
Posts: 518
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Kate,
I am so sorry to hear your news. But am glad you caught things early and have a good onc who will figure this all out.
We are like a special family when one hurts we all hurt.
You are in my thoughts and prayers.
Donna
__________________
Donna
Crystal Lake, IL
Diagnosed 8/4/06 at age 54
Lumpectomy 8/30/06
Stage llA, grade 3, ER/PR-, Her2++
1.7 cm tumor, 1+ lymph node out of 9
Completed 4 A/C, & 4 Taxol with Herceptin
36 rads completed 5/16/07
Mammograms, 7/07 clear
fractured ribs in radiated area 10/07
Finished Herceptin 12/27/07
Mammogram,CT,tumor markers 1/08 - small lung nodules in radiated area, repeated tests 3/08 stable
Mammogram,CT ,tumor markers 6/08 stable
NED 2 years!!
3 years !!!
4years!!!!
4 years, 10 months and 8 day NED, calling it 5 years!!!
Official 5 years 8/30/2011
8/31/ 2012 - 6 years!!!!!!
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07-14-2007, 02:55 PM
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#10
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Senior Member
Join Date: Jun 2007
Posts: 37
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Kate. So sorry for your news, but good going for caching it early. Keep us posted and use those big guns. Know you'll beat back those little beasties in no time. Will keep you in prayers and sending you cyber hugs.<<<<<<HUGS>>>>>
Kacey
__________________
dx 9-13-05 MRM (lt)on 9-19-05
IDC stage llb grade 2 3/24 nodes+
ER/PR- Her2+++
Groshong placed 10-13-05 and chemo started
TCH x6 and continue Herceptin for one year every 3 wks
Rads x 33 (at the end of chemo) finished 4-01-06
20 months NED
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07-14-2007, 06:11 PM
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#11
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Senior Member
Join Date: Nov 2005
Location: Lincoln, Rhode Island
Posts: 371
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Dear Kate,
I am so sorry too how I hate this beast! But they have alot of treatments and you will do fine. Please know your are in my prayers. Keep the faith my friend.
__________________
Love and Hope
Karen
IDC
DX 1998 STAGE I ER+/ PR+
AC CHEMO TILL FEB 1999
Tamxofin till 2001
2001 exstensive liver mets and mets to lungs
Started weekly taxol
Jan 2002 found out I was strongly HER2POS+++ started herceptin continued with taxol and herceptin till June 2002 then from June 2002 till Jan 2005 just herceptin and Arimidex
2005 Navelbine herceptin had RFA Then back on taxol with herceptin
April 2006 progression again went on clinical trial with tykrerb/herceptin progressed on the started Xeloda/ herceptin
Feb 2007 started Doxil
August 2007 Taxotere,Carboplatin and Herceptin exstensive mets to liver and pancreas
October 2007 Had to stop Carboplatin due to sever allergic reaction
Jan 2008
Stopped Taxotere due to progression now on Gemzar and Herceptin
March 2008 Starting Carboplatin, Abraxane, and Herceptin.
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07-14-2007, 10:20 PM
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#12
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Senior Member
Join Date: Dec 2006
Location: Oregon
Posts: 715
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Green Shoes and Army Boots
Dear Kate,
I am sitting here going ...., ...., double-damn. like some of the others. I am bummed and mad about this, but ready to put on my green shoes and army boots to join the rest of our army to support and help you in your next treatment plan. Thank goodness for all the knowledgeable friends who have already posted their advice.
Thank goodness you asked for the CT scan and the MRI. I will be on vacation when you go next week for your appointment. You will be in my prayers. I know you are a well-informed fighter. So you go girl, and we will be standing right there with you.
Love to you, Catherine
__________________
Catherine
Found my own lump in the shower
April 2006 at the age of 58
Stage IIB, ER- PR- HER2+++ multi focal tumors, largest 2.3cm
Chemo first: AC/Taxol over 16 weeks
Bilateral mastectomy Sep 06
33 rads after the surgery
1 year of Herceptin completed Dec 07
15 years and no recurrence as of April 2021
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07-14-2007, 10:40 PM
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#13
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Senior Member
Join Date: May 2006
Posts: 143
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Dear Kate:
I'm so sorry to hear this, but glad you caught things early and know that treatment will go well. Please let us know what happens. Thinking of you
Linda
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07-16-2007, 05:17 PM
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#14
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Senior Member
Join Date: Nov 2006
Location: The Hudson Valley, New York
Posts: 124
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Kate,
I just got home from work and Sue told me about your post. That sucks. Of course we're thinking about you and know that if information is of any help in all of this (and it certainly is) than you are one of the best equipped.
What can be said? You were of such great help to us when we first came here, and you continue to be.
We' re thinking of you.
-Kevin
__________________
---Kevin and Sue---
Dx'd 10/06 IDC grade III/III
Er- pr- HER2 3+
MRM right breast 12/5/06
nodes negative
same day reconstruction started
(implants)
Stage II (2.2 cm tumor)
fairly extensive DCIS
Ct and Bone scans clean
Port placement 12/26/06
AC (4 cycles DD)to begin 1/2/07
Taxol/Taxotere (4 cycles DD)
Herceptin for one year
"There is no distinction between the one who gives, the one who receives, and the gift itself."- Hahn
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07-17-2007, 06:13 PM
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#15
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Senior Member
Join Date: Feb 2006
Location: Acworth, GA
Posts: 2,104
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Thank you
I want to thank everyone for their wonderful support at this time. You have provided me with a good bit of information that I can use in my discussion with my oncologist on Friday. That is when we will come up with a treatment plan. Thank you again and I will keep you posted.
__________________
Kate
Stage IIIC Diagnosed Oct 25, 2005 (age 58)
ER/PR-, HER2+++, grade 3, Ploidy/DNA index: Aneuploid/1.61, S-phase: 24.2%
Neoadjunct chemo: 4 A/C; 4 Taxatore
Bilateral mastectomy June 8, 2006
14 of 26 nodes positive
Herceptin June 22, 2006 - April 20, 2007
Radiation (X35) July 24-September 11, 2006
BRCA1/BRCA2 negative
Stage IV lung mets July 13, 2007 - TCH
Single brain met - August 6, 2007 -CyberKnife
Oct 2007 - clear brain MRI and lung mets shrinking.
March 2008 lung met progression, brain still clear - begin Tykerb/Xeloda/Ixempra
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07-14-2007, 10:51 PM
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#16
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Member
Join Date: Feb 2007
Posts: 23
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lung mets - experience varies
ummm, i was shocked at someone's post that lung mets seem easy to get rid of? huh? i think some of us cancer patients live in different worlds than others! like those that say breast cancer is a"chronic disease" - chronic for a small handful of very unique and lucky stage IVs. of course for all who never have to deal with mets, life is an entirely diferent world anyway.
I wanted to say Kate that a respected oncologist/researcher i know who specializes in bc mets told me xeloda seems to be a good chemo for lungs. indeed tykerb/xeloda was the only thing that ever worked for me, but I'm extremely recalcitrant and it only worked for 7 weeks. but i know others who've gotten at least a year out of the combo. personally i found it very easy to tolerate, and i'd had many many chemo combos before that.
just another suggestion for you, you have many many options, hang in there, one day at a time!
Theresa
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07-15-2007, 02:08 AM
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#17
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Senior Member
Join Date: May 2006
Posts: 157
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Kate,
I am deeply sorry for your news. I can imagine what you are feeling right now, because I have been there. Just hang in there, and try not to think too much of what is happenig to you right now, I know itt is hard, but try to keep busy doing whatever you like most, it helps a lot.
I was also diagnosed with Stage IIIC, and in less than a year I became Stage IV with lung and liver mets. And I felt what you are feeling right now, but I can assure you that things do get better. In fact, today I had a big party to celebrate my son's 6th birthday, everything organized by me,a nd I did not even remembered for one single moment I have Stage IV breast cancer.
I am er/pr-, hers2+, and I have been on nalvabine/herceptin for a year now, and my small liver mets are all gone, and all my small lung mets (both lungs) are almost gone, 1 just have a less than 1 cm met that they could hardly see on this scan, and a stable lymph node. So herceptin/nalvabine has been very good for me. And Nalvabine is a very easy drug, no premedications, no hair loss, no nausea, just a little bit the day of treatment, and some neuropathy. It is very doable.
I hope and pray that you find the right treatment for you very fast. When you do, things will go back to "almost" normal again. If you have any questions, PM me, I would like to help you through these terrifying moments. Hang in there.
Hugs, and prayers,
KarlaV.
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07-15-2007, 07:16 AM
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#18
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Deceased
Join Date: Oct 2005
Location: Chadds Ford, Pa
Posts: 206
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Hi Kate,
I'm am so sorry that you get to be a member of the stage IV club, but I know you know that lots of women on this sight live full lives with this, as I like to think of it, chronic disease state. Anyway, I've been stage IV for almost two years, with liver mets first and lung mets added to the mix in May. My quality of life has been very good. I work, travel and have fun with my family and friends. I hug my kids a lot (and they're teenage boys and hate that!) and love and appreciate my husband every day. I will not let this disease take my living from me!
On the battle front, after only 6 weeks on Xeloda/Tykerb my lung mets are GONE and my small liver mets are GONE and my larger liver mets are all much smaller. There is hope out there! Please keep us posted on what you and your onc decide.
You will be in my thoughts and prayers.
Donna
__________________
Donna
Diagnosed 2/04 - Invasive ductal - no clean margins
node negative - er+pr+, her2++
Mastectomy 4/04 - 4 rounds AC
9/05 - mets to liver treated with carbo/ixabipelone/herceptin
3/06 - complete remission
9/06 - new liver mets, starting Taxotere/Herceptin
1/07 -Liver mets stable, staying on Herceptin
5/07 - Liver, lung progression - starting T/X
12/07 - Liver, lung progression - starting weekly Navilbene/Herceptin
4/08 - Liver progression - started Abraxane, Carbo, Tykerb and Herceptin
7/08 - Liver Progression - started Gemzar, Avastin and Tykerb
10/08 - Liver progression - starting Doxil
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07-15-2007, 08:28 AM
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#19
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Senior Member
Join Date: Feb 2007
Location: Paris, France
Posts: 858
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Hi Kate, I saw your post yesterday and wanted to write but couldn't I was so mad. Why does this happen to such a nice person who has been supporting everybody on this forum?!!??! Your onc. seems to do right so see what he recommends. Fight all the way up the hill once more! I know it is easier to say than to do, but please give us news. You will be in my mind and heart every single day.
Michka.
__________________
08.2006 3 cm IDC Stage 2-3, HER2 3+ ER+90% PR 20%
FEC, Taxol+ Herceptin, Mastectomy, Radiation, Herceptin 1 year followed by Tykerb 1 year,Aromasin /Faslodex
12.2010 Mets to liver,Herceptin+Tykerb
03.2011 Liver resection ER+70% PR-
04.2011 Herceptin+Navelbine+750mg Tykerb
06.2011 Liver ned, Met to sternum. Added Zometa 09.2011 Cyberknife for sternum
11.2011 Pet clear. Stop Navelbine, continuing on Hercpetin+Tykerb+Aromasin
02.2012 Mets to lungs, nodes, liver
04.2012 TDM1, Ned in 07.2012
04.2015 Stop TDM1/Kadcyla, still Ned, liver problems
04.2016 Liver mets. Back on Kadcyla
08.2016 Kadcyla stopped working. mets to liver lungs bones
09.2016 Biopsy to liver. no more HER2, still ER+
09.2016 CMF Afinitor/Aromasin/ Xgeva.Met to eye muscle Cyberknife
01.2017 Gemzar/Carboplatin/ Ibrance/Faslodex then Taxotere
02.2017 30 micro mets to brain breathing getting worse and worse
04.2017 Liquid biopsy/CTC indicates HER2 again. Start Herceptin with Halaven
06.2017 all tumors shrunk 60% . more micro mets to brain (1mm mets) no symptoms
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07-15-2007, 10:51 AM
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#20
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Senior Member
Join Date: Sep 2005
Location: Philadelphia
Posts: 301
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Kate-
I am so sorry to hear of your progression. My mets was first to lungs, and my onc chose xeloda, and I chose the clinial trial if xeloda with tykerb, and that kicked things back quite a bit for some time.
But everyone is differerent, and the navalbine and taxanes are also an option. Like Lolly mentioned, I would definitely keep the herceptin...
Please keep us posted, and you are in our thoughts and prayers...
Kind regards,
__________________
Shell
init diag 3/17/03-stage IIIC
ER-/PR-/HER2+++
CET x4 neo-adjuvant
lump & SNB 8/03
CET x2
radiation and herceptin/navelbine 11-03-1/04
1st reoccur to lymph nodes 8/04
complete axillary dissection 12/04
herceptin/taxotere til progression (lungs) 3/05
xeloda w/out lapatinib trial 6/05
lapatinib/tykerb added 4/06
ended trial 8/06 due to progression
doxil / avastin 11/06-12/06 - wasn't working
navelbine/herceptin/avastin 12/06/3/07 - progression
gemzar/carboplatin/tykerb 4/07
mri shows extensive mets to bone in pelvic area 6/07
switched to abraxane (3 on/1 off) + tykerb 6/07
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