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Kate, I'm sorry to hear this, but you sound ready to fight and beat this back, and that's good.
Knowing what I know now, my first inclination if I were in your shoes, would be to request to be put back on Herceptin and ask your onc to recommend a chemo to add for synergy. Navelbine has worked great for me in the past, and I have a friend who had lung mets go into remission on the combo of Navelbine/Herceptin. Other options would be Abraxane, a platinum such as carbo, or Xeloda. If you can, save the Tykerb for such a time as you need it if Herceptin and chemo doesn't keep things in check.
Just my opinion as to what I would do to stretch out options.
Best of luck. I know you're very disapointed right now, but you can beat these mets back into submission. Hang in there and keep us posted.
<3 Lolly
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.
Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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