Lani,
You are about 1000% ahead of me as far as being well read up,
but from what I understand about TOPO is that the latest info about Her2+ and TOPO flies in the face of what was thought previously. When Her2+ and Herceptin enters the equation, all of a sudden the anthrcycline is not necessary in chemo to achieve similar results (i.e the latest stats on TCH - San Antonio). The TOPO positive people do better in general, and that is true in HER2+ whether they do the AC+TH or TCH. I was given this answer when I asked our onc if the fact that Ruth was responding well to the TCH meant that she was TOPO negative as the other onc (not a bc specialist) had given us the hard core insistence that Ruth must have an anthracycline in case she was TOPO positive. I think I read something early on by Dr. Pegram (sp?) that indicates something similar.
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