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You don't say where you are located
Dr. Mark Pegram shows pictures at conferences of patients with extensive metastatic breast cancer with chest wall involvement and even fungating lesions which have responded to the combination of herceptin plus avastin (he has a clinical trial going) He is leaving/has left (his last conference lecture showed a slide with him already being at the Miami Cancer Center) UCLA for Miami. I don't know if his clinical trial will go with him, but look at the NCI clinical trial site.
Others here can give you reports of personal experience on other herceptin/tykerb/chemo combinations.
Good luck!
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