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Old 07-05-2007, 09:32 PM   #1
Lolly
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Location: Oregon
Posts: 1,756
Eric, when I was on Herceptin and in and out of NED, my onc would always suggest reverting back to weekly Herceptin when it became necessary to combine it with chemo for that one-two punch that would hopefully knock me back into NED or stable disease...
I never had a triplet combo, because he feels the side effects are indeed more severe than with a single chemo. I had very good results from this strategy, and now that I'm on Tykerb/Abraxane the plan remains in place; use of single chemo's with Tykerb as necessary.
I don't know specifically about Taxotere side effects as that's one I've never had yet, but I know others here have info on that. I just wanted you to know I'm thinking of you and Caryn and to reassure you that a single chemo/Herceptin combo can be very effective and extend options.

<3 Lolly
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Sept.'99 - Dx.Stage IIIB, IDC ER/PR-, HER2+++ by IHC, confirmed '04 by FISH. Left MRM, AC x's 4, Taxol x's 4, 33 Rads, finishing Tx May 2000. Jan.'01 - local/regional recurrence, Stage IV. Herceptin/Navelbine weekly till NED August 2001, then maintenance Herceptin. Right Mast. April 2002. Local/Regional recurrence April '04, Herceptin plus/minus chemo until May '07. Gemzar added from Feb.'07-April '07; Tykerb/Abraxane until August '07, back on Herceptin plus Taxotere and Xeloda Sept. '07. Stopped T/X Nov. '07, stopped Herceptin Dec. '07, started Avastin/Taxol/Carboplatin Dec. '07. Progression in chest skin, stopped TAC March '03, started radiation.

Herceptin has served as the "Backbone" of my treatment strategy for over 6 years, giving me great quality of life. In 2005, I was privileged to participate in the University of Washington/Seattle HER2 Vaccine Trial.
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Old 07-06-2007, 12:48 AM   #2
Kavy
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Hi, Eric,
Taxotere/Herceptin is a very good combo, and I am glad Caryn will get Herceptin again. I had this combo for 6 months and it was pretty easy on me. I did not feel tired, I had much more energy than I have now with Nalvabine, and I did not lose my taste. But my hair did not grew back while on it, and my big toe nails both fell off. My finger nails got pretty bad, and I thought they would fall off too, because they were all half way loose, but I used tree tea oil on them, and they got back to normal. I used to bring a plastic bag with ice to the infusion room to put my fingers in it, because I read it helped the nails not to fall off, but it did not help me though.
I have tingling and numbness in my hands and feet, and my legs feel heavy sometimes. My doctor says that it is from Taxotere, but I think it is from Nalvabine.
I was very disappointed when my doctor decided to change from Taxotere to Nalvabine, because it was very doable, and it was every 3 weeks.
I hope and pray that this combo will take Caryn to NEDland.
KarlaV.
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Old 07-06-2007, 05:26 AM   #3
Sheila
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Eric
I am on Taxol rather than Taxotere with Herceptin and Avastin...the Taxol is very similar, I get it weekly x3 then off a week, they just switched my Herceptin to every other week, and Abraxane every other week...the Abraxane is new and blocks the blood supply to the tumor, the Herceptin has been my backbone in treatment for 4 years. I have had very few effects from the Taxol...did lose my hair after 3 weekly, but no nausea, tired from the premeds they give me, but my counts are good so far....Taxotere hopefully in the same family will be just as easy...although I wonder why no Abraxane, also the same family with minimal side effects....I couldn't get it as the insurance would only pay for Taxol, same effect but CHEAPER...maybe ask about adding the Avastin....my nodes are less than half the size after 3 weekly treatments!
I will be thinking of you and your wife.
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"Be kinder than necessary, for everyone you meet
is fighting some kind of battle."



Hugs & Blessings
Sheila
Diagnosed at age 49.99999 2/21/2002 via Mammography (Calcifications)
Core Biopsy 2/22/02
L. Mastectomy 2/25/2002
Stage 1, 0.7cm IDC, Node Neg from 19 nodes Her2+++ ER PR Neg
6/2003 Reconstruction W/ Tissue Expander, Silicone Implant
9/2003 Stage IV with Mets to Supraclavicular nodes
9/2003 Began Herceptin every 3 weeks
3/2006 Xeloda 2500mg/Herceptin for recurrence to neck nodes
3/2007 Added back the Xeloda with Herceptin for continued mets to nodes
5/2007 Taken Off Xeloda, no longer working
6/14/07 Taxol/Herceptin/Avastin
3/26 - 5/28/08 Taxol Holiday Whopeeeeeeeee
5/29 2008 Back on Taxol w Herceptin q 2 weeks
4/2009 Progression on Taxol & Paralyzed L Vocal Cord from Nodes Pressing on Nerve
5/2009 Begin Rx with Navelbine/Herceptin
11/09 Progression on Navelbine
Fought for and started Tykerb/Herceptin...nodes are melting!!!!!
2/2010 Back to Avastin/Herceptin
5/2010 Switched to Metronomic Chemo with Herceptin...Cytoxan and Methotrexate
Pericardial Window Surgery to Drain Pericardial Effusion
7/2010 Back to walking a mile a day...YEAH!!!!
9/2010 Nodes are back with a vengence in neck
Qualified for TDM-1 EAP
10/6/10 Begin my miracle drug, TDM-1
Mixed response, shrinking internal nodes, progression skin mets after 3 treatments
12/6/10 Started Halaven (Eribulen) /Herceptin excellent results in 2 treatments
2/2011 I CELEBRATE my 9 YEAR MARK!!!!!!!!!!!!!
7/5/11 begin Gemzar /Herceptin for node progression
2/8/2012 Gemzar stopped, Continue Herceptin
2/20/2012 Begin Tomo Radiation to Neck Nodes
2/21/2012 I CELEBRATE 10 YEARS
5/12/2012 BeganTaxotere/ Herceptin is my next miracle for new node progression
6/28/12 Stopped Taxotere due to pregression, Started Perjeta/Herceptin
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