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Harald, when I started at the initial dose of 5 Tykerb pills a day, the fatigue was quite pronounced. After lowering the dose to 3 pills a day, the fatigue was quite minimal.
Just recently we raised the dose to 4 pills a day, and the fatigue has once again increased. So for me, the fatigue seems to definitely be dose related. Since I got my great results while on just 3 pills a day, I think I will be discussing with my onc reducing back to that level.
She should discuss it with her onc and see if a dose reduction might make sense for her.
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